Evidence map›Paper›PMID 34955016›Full record

ArticleBiochemistry2022

Enhanced Triplex Hybridization of DNA and RNA via Syndiotactic Side Chain Presentation in Minimal bPNAs.

Sarah Rundell, Oliver Munyaradzi, Dennis Bong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Synthesis of Bifacial Peptide Nucleic Acids with Diketopiperazine Backbones.Synlett : accounts and rapid communications in synthetic organic chemistry · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sarah RundellDepartment of Chemistry & Biochemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, Ohio 43210, United States.
Oliver MunyaradziDepartment of Chemistry & Biochemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, Ohio 43210, United States.
Dennis BongDepartment of Chemistry & Biochemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, Ohio 43210, United States.ORCID 0000-0003-3778-9183
The Ohio State University · US

Funding

Development of Fluorogenic Aptamers for Detection and Deactivation of Erbb Receptors using Bifacial PNAR01GM111995 · NIGMS · OHIO STATE UNIVERSITY · PI BONG, DENNIS · 2015 to 2019
$1.4M
Synthetic strategies for non-canonical hybridization to structural motifs in RNAR01GM143543 · NIGMS · OHIO STATE UNIVERSITY · PI BONG, DENNIS · 2021 to 2024
$1.4M
NIGMS NIH HHS R01 GM111995NIGMS NIH HHS R01 GM143543
6 · The paper itself

Abstract

General design principles for recognition at noncanonical interfaces of DNA and RNA remain elusive. Triplex hybridization of bifacial peptide nucleic acids (bPNAs) with oligo-T/U DNAs and RNAs is a robust recognition platform that can be used to define structure-function relationships in synthetic triplex formation. To this end, a set of minimal (

Indexed as

DNANucleic Acid ConformationNucleic Acid HybridizationPeptide Nucleic AcidsRNAThermodynamicsThymineUracilDNAPeptide Nucleic AcidsRNAThymineUracil

Identifiers

PMID34955016
PMCPMC9361178
OpenAlexW4200203528

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.