Evidence map›Paper›PMID 34958113›Full record

ArticleOncology reports2022

Decursin inhibits tumor progression in head and neck squamous cell carcinoma by downregulating CXCR7 expression

Mina Joo, Jong Beom Heo, Solbi Kim, Nayoung Kim, Heung Jin Jeon, Yueun An, Gyu-Yong Song, Jin-Man Kim, Hyo Jin Lee

Open access · hybridAbstract read
In one paragraph

Article in Oncology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Identification and validation of an immune-derived multiple programmed cell death index for predicting clinical outcomes, molecular subtyping, and drug sensitivity in lung adenocarcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mina JooDepartment of Medical Science, Chungnam National University, Daejeon 35015, Republic of Korea.
Jong Beom HeoCollege of Pharmacy, Chungnam National University, Daejeon 35015, Republic of Korea.
Solbi KimDepartment of Medical Science, Chungnam National University, Daejeon 35015, Republic of Korea.
Nayoung KimDepartment of Medical Science, Chungnam National University, Daejeon 35015, Republic of Korea.
Heung Jin JeonInfection Control Convergence Research Center, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.
Yueun AnInfection Control Convergence Research Center, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.
Gyu-Yong SongCollege of Pharmacy, Chungnam National University, Daejeon 35015, Republic of Korea.
Jin-Man KimDepartment of Pathology, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.
Hyo Jin LeeInfection Control Convergence Research Center, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.
Chungnam National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CXC chemokine receptor 7 (CXCR7) is frequently overexpressed in cancer and plays a significant role in tumor growth and metastasis. Consequently, inhibition of CXCR7 is important for treatment strategies. However, little is known concerning the biological role of CXCR7 and its underlying mechanisms in head and neck squamous cell carcinoma (HNSCC). The present study investigated the role of CXCR7 in HNSCC, as well as the effects of decursin, a pyranocoumarin compound isolated from

Indexed as

BenzopyransButyratesCell Line, TumorCell MovementCell ProliferationDisease ProgressionDown-RegulationEnzyme ActivatorsHead and Neck NeoplasmsHumansReceptors, CXCRSquamous Cell Carcinoma of Head and NeckACKR3 protein, humanBenzopyransButyratesdecursinEnzyme ActivatorsReceptors, CXCRc‑MycCXC chemokine receptor 7decursinhead and neck cancerinvasionmigrationproliferationsignal transducers and activators of transcription 3

Identifiers

PMID34958113
PMCPMC8759107
OpenAlexW4200060284

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.