Evidence map›Paper›PMID 34959330›Full record

ArticlePharmaceutics2021

Dually Cross-Linked Core-Shell Structure Nanohydrogel with Redox-Responsive Degradability for Intracellular Delivery.

Siyuan Deng, Maria Rosa Gigliobianco, Emin Mijit, Marco Minicucci, Manuela Cortese, Barbara Campisi, Dario Voinovich, Michela Battistelli, Sara Salucci, Pietro Gobbi and 5 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Siyuan DengSchool of Pharmacy, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
Maria Rosa GigliobiancoPercuros B.V., Zernikedreef 8, 2333 CL Leiden, The Netherlands.ORCID 0000-0002-9699-4673
Emin MijitPhysics Division, School of Science and Technology, University of Camerino, Via Madonna delle Carceri 9, 62032 Camerino, Italy.
Marco MinicucciPhysics Division, School of Science and Technology, University of Camerino, Via Madonna delle Carceri 9, 62032 Camerino, Italy.ORCID 0000-0001-6459-7000
Manuela CorteseSchool of Pharmacy, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.ORCID 0000-0002-7622-1657
Barbara CampisiDepartment of Economic, Business, Mathematic and Statistical Sciences, University of Trieste, 34127 Trieste, Italy.ORCID 0000-0003-0429-0394
Dario VoinovichDepartment of Chemical and Pharmaceutical Science, University of Trieste, P. le Europa 1, 34127 Trieste, Italy.ORCID 0000-0003-3830-8038
Michela BattistelliInstitute of Morphological Sciences, University of Urbino, Via Ca' le Suore 2, 61029 Urbino, Italy.
Sara SalucciCellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-3507-4451
Pietro GobbiInstitute of Morphological Sciences, University of Urbino, Via Ca' le Suore 2, 61029 Urbino, Italy.ORCID 0000-0003-4705-0833
Giulio LupidiSchool of Pharmacy, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
Giorgia ZambitoDepartment of Radiology and Nuclear Medicine, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands.
Laura MezzanotteDepartment of Radiology and Nuclear Medicine, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0001-5592-8904
Roberta CensiSchool of Pharmacy, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
Piera Di MartinoDipartimento di Farmacia, Università "G. D'Annunzio" Chieti e Pescara, Via dei Vestini, 1, 66100 Chieti, Italy.ORCID 0000-0002-7657-3556
Università di Camerino · ITErasmus MC · NLUniversity of Trieste · ITUniversity of Urbino · ITPercuros (Netherlands) · NLUniversity of Bologna · ITUniversity of Chieti-Pescara · IT

Funding

European Commission 675743European Commission 777682
6 · The paper itself

Abstract

A redox-responsive nanocarrier is a promising strategy for the intracellular drug release because it protects the payload, prevents its undesirable leakage during extracellular transport, and favors site-specific drug delivery. In this study, we developed a novel redox responsive core-shell structure nanohydrogel prepared by a water in oil nanoemulsion method using two biocompatible synthetic polymers: vinyl sulfonated poly(

Indexed as

cancer immunotherapydrug delivery systemfactor influence studymacromoleculenanocapsuleperoxidase-like enzymatic activity

Identifiers

PMID34959330
PMCPMC8708258
OpenAlexW3217714442

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.