Evidence map›Paper›PMID 34959948›Full record

ReviewNutrients2021

Strategies to Mitigate Chemotherapy and Radiation Toxicities That Affect Eating.

Peter M Anderson, Stefanie M Thomas, Shauna Sartoski, Jacob G Scott, Kaitlin Sobilo, Sara Bewley, Laura K Salvador, Maritza Salazar-Abshire

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Review
  6. Article
  7. Perceived food literacy in women with gynecologic cancer receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Lumbrokinase Extracted fromBiomolecules · 2024
    Article
  15. Review
  16. Probiotics in the management of radiation-induced oral mucositis.Frontiers in cellular and infection microbiology · 2024
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Peter M AndersonPediatric Hematology/Oncology and Bone Marrow Transplant, Cleveland Clinic Children's, Cleveland, OH 44195, USA.ORCID 0000-0002-0011-0969
Stefanie M ThomasPediatric Hematology/Oncology and Bone Marrow Transplant, Cleveland Clinic Children's, Cleveland, OH 44195, USA.
Shauna SartoskiPediatric Hematology/Oncology and Bone Marrow Transplant, Cleveland Clinic Children's, Cleveland, OH 44195, USA.
Jacob G ScottTaussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Kaitlin SobiloPediatric Hematology/Oncology and Bone Marrow Transplant, Cleveland Clinic Children's, Cleveland, OH 44195, USA.
Sara BewleyPediatric Hematology/Oncology and Bone Marrow Transplant, Cleveland Clinic Children's, Cleveland, OH 44195, USA.
Laura K SalvadorDepartment of Pediatrics, MD Anderson Cancer Center, Houston, TX 77030, USA.
Maritza Salazar-AbshireDepartment of Pediatrics, MD Anderson Cancer Center, Houston, TX 77030, USA.
Cleveland Clinic · USThe University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer and its therapy is commonly associated with a variety of side effects that impact eating behaviors that reduce nutritional intake. This review will outline potential causes of chemotherapy and radiation damage as well as approaches for the amelioration of the side effects of cancer during therapy.

methodsInformation for clinicians, patients, and their caregivers about toxicity mitigation including nausea reduction, damage to epithelial structures such as skin and mucosa, organ toxicity, and education is reviewed.

resultsHow to anticipate, reduce, and prevent some toxicities encountered during chemotherapy and radiation is detailed with the goal to improve eating behaviors. Strategies for health care professionals, caregivers, and patients to consider include (a) the reduction in nausea and vomiting, (b) decreasing damage to the mucosa, (c) avoiding a catabolic state and muscle wasting (sarcopenia), and (d) developing therapeutic alliances with patients, caregivers, and oncologists.

conclusionsAlthough the reduction of side effects involves anticipatory guidance and proactive team effort (e.g., forward observation, electronic interactions, patient reported outcomes), toxicity reduction can be satisfying for not only the patient, but everyone involved in cancer care.

Indexed as

Antineoplastic AgentsCaregiversEatingFeeding BehaviorHumansNauseaNeoplasmsPatient Care TeamRadiotherapySarcopeniaVomitingAntineoplastic Agentsanti-emeticscancer treatment side effectscatabolic statenauseaoutpatient chemotherapysarcopeniasterotactic body radiotherapy (SBRT)therapeutic alliance

Identifiers

PMID34959948
PMCPMC8706251
OpenAlexW4200566619

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.