Evidence mapPaperPMID 34959986Full record

ArticleNutrients2021

Dietary Intake of Advanced Glycation End Products (AGEs) and Mortality among Individuals with Colorectal Cancer.

Ziling Mao, Elom K Aglago, Zhiwei Zhao, Casper Schalkwijk, Li Jiao, Heinz Freisling, Elisabete Weiderpass, David J Hughes, Anne Kirstine Eriksen, Anne Tjønneland and 27 more

Abstract readMulticenter Study
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Ziling MaoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0001-9601-2468
Elom K AglagoSection of Nutrition and Metabolism, International Agency for Research on Cancer, World Health Organization (IARC-WHO), 69372 Lyon, France.
Zhiwei ZhaoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Casper SchalkwijkDepartment of Internal Medicine, School for Cardiovascular Diseases (CARIM), Maastricht University, 6229ER Maastricht, The Netherlands.
Li JiaoBaylor College of Medicine, 2002 Holcombe Blvd, Houston, TX 77030, USA.ORCID 0000-0002-0237-0262
Heinz FreislingSection of Nutrition and Metabolism, International Agency for Research on Cancer, World Health Organization (IARC-WHO), 69372 Lyon, France.ORCID 0000-0001-8648-4998
Elisabete WeiderpassSection of Nutrition and Metabolism, International Agency for Research on Cancer, World Health Organization (IARC-WHO), 69372 Lyon, France.ORCID 0000-0003-2237-0128
David J HughesCancer Biology and Therapeutics Group, School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.ORCID 0000-0003-1668-8770
Anne Kirstine EriksenDanish Cancer Society Research Center, Diet, Genes and Environment Nutrition and Biomarkers (NAB), Strandboulevarden 49, DK-2100 Copenhagen, Denmark.
Anne TjønnelandDanish Cancer Society Research Center, Diet, Genes and Environment Nutrition and Biomarkers (NAB), Strandboulevarden 49, DK-2100 Copenhagen, Denmark.
Gianluca SeveriCESP (UMR1018), Faculté de Médecine Université Paris-Saclay, Inserm, Gustave Roussy, 94805 Villejuif, France.
Joseph RothwellCESP (UMR1018), Faculté de Médecine Université Paris-Saclay, Inserm, Gustave Roussy, 94805 Villejuif, France.
Marie-Christine Boutron-RuaultCESP (UMR1018), Faculté de Médecine Université Paris-Saclay, Inserm, Gustave Roussy, 94805 Villejuif, France.
Verena KatzkeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Matthias B SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany.ORCID 0000-0002-0830-5277
Anna BirukovDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany.ORCID 0000-0002-8306-3351
Vittorio KroghEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via Venezian, 20133 Milan, Italy.ORCID 0000-0003-0122-8624
Salvatore PanicoDipartmento Di Medicina Clinica E Chirurgia, Federico II University, 80131 Naples, Italy.
Rosario TuminoCancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), 97100 Ragusa, Italy.
Fulvio RicceriDepartment of Clinical and Biological Sciences, University of Turin, 10043 Turin, Italy.
H Bas Bueno-de-MesquitaCentre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), 3720 Bilthoven, The Netherlands.
Roel C H VermeulenDivision of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, 80178 Utrecht, The Netherlands.
Inger T GramDepartment of Community Medicine, University of Tromsø, The Arctic University of Norway, 9010 Tromsø, Norway.ORCID 0000-0002-0031-4152
Guri SkeieDepartment of Community Medicine, University of Tromsø, The Arctic University of Norway, 9010 Tromsø, Norway.ORCID 0000-0003-2476-4251
Torkjel M SandangerDepartment of Community Medicine, University of Tromsø, The Arctic University of Norway, 9010 Tromsø, Norway.
J Ramón QuirósPublic Health Directorate, 33080 Asturias, Spain.
Marta Crous-BouUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO)-Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Spain.
Maria-Jose SánchezEscuela Andaluza de Salud Pública (EASP), 18011 Granada, Spain.ORCID 0000-0003-4817-0757
Pilar AmianoMinistry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, 20013 San Sebastian, Spain.
María-Dolores ChirlaqueSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Aurelio Barricarte GurreaSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Jonas ManjerDepartment of Surgery, Skåne University Hospital Malmö, Lund University, SE-221 00 Malmö, Sweden.
Ingegerd JohanssonDepartment of Epidemiology and Clinical Medicine, Umeå University, SE-901 87 Umeå, Sweden.ORCID 0000-0002-9227-8434
Aurora Perez-CornagoCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
Mazda JenabSection of Nutrition and Metabolism, International Agency for Research on Cancer, World Health Organization (IARC-WHO), 69372 Lyon, France.ORCID 0000-0002-0573-1852
Veronika FedirkoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-7805-9913

Funding

Cancer Research UK 29017Medical Research Council MC_UU_12015/1Medical Research Council MR/N003284/1World Health Organization 001
6 · The paper itself

Abstract

Advanced glycation end-products (AGEs) may promote oxidative stress and inflammation and have been linked to multiple chronic diseases, including cancer. However, the association of AGEs with mortality after colorectal cancer (CRC) diagnosis has not been previously investigated. Multivariable Cox proportional hazards models were used to calculate hazard ratios and corresponding 95% confidence intervals for associations between dietary intake of AGEs with CRC-specific and all-cause mortality among 5801 participant cases diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition study between 1993 and 2013. Dietary intakes of AGEs were estimated using country-specific dietary questionnaires, linked to an AGE database, that accounted for food preparation and processing. During a median of 58 months of follow-up, 2421 cases died (1841 from CRC). Individually or combined, dietary intakes of AGEs were not associated with all-cause and CRC-specific mortality among cases. However, there was a suggestion for a positive association between AGEs and all-cause or CRC-specific mortality among CRC cases without type II diabetes (all-cause,

Indexed as

EatingAgedCause of DeathColorectal NeoplasmsDietDiet SurveysEuropeFemaleGlycation End Products, AdvancedHumansMaleMiddle AgedProportional Hazards ModelsProspective StudiesGlycation End Products, Advancedadvanced glycation end-productsall-cause mortalitycolorectal cancer mortalitydietary advanced glycation end-products

Identifiers

PMID34959986
PMCPMC8704988

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.