Evidence map›Paper›PMID 34961221›Full record

ReviewPlants (Basel, Switzerland)2021

Shadma Wahab, Sivakumar Annadurai, Shahabe Saquib Abullais, Gotam Das, Wasim Ahmad, Md Faruque Ahmad, Geetha Kandasamy, Rajalakshimi Vasudevan, Md Sajid Ali, Mohd Amir

Open access · goldAbstract readReview
In one paragraph

Review in Plants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 3 pooled it
32.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 3 syntheses or guidelines pooled it, 348 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Article
  7. Combined Omeprazole andInternational journal of molecular sciences · 2026
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Formulation and Biological Evaluation ofAntioxidants (Basel, Switzerland) · 2026
    Article
  16. Mechanisms ofMedicina (Kaunas, Lithuania) · 2026
    Review
  17. Review
  18. Article
  19. Complete genome sequencing ofFrontiers in microbiology · 2026
    Article
  20. Review

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Shadma WahabDepartment of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia.ORCID 0000-0001-9941-2918
Sivakumar AnnaduraiDepartment of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia.
Shahabe Saquib AbullaisDepartment of Periodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha 61421, Saudi Arabia.
Gotam DasDepartment of Prosthodontics, College of Dentistry, King Khalid University, Abha 61421, Saudi Arabia.ORCID 0000-0001-9506-6456
Wasim AhmadDepartment of Pharmacy, Mohammed Al-Mana College for Medical Sciences, Safaa, Dammam 34222, Saudi Arabia.ORCID 0000-0003-2639-9200
Md Faruque AhmadDepartment of Clinical Nutrition, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia.
Geetha KandasamyDepartment of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia.
Rajalakshimi VasudevanDepartment of Pharmacology, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia.
Md Sajid AliDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.ORCID 0000-0001-5582-0119
Mohd AmirDepartment of Natural Products and Alternative Medicines, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.
King Khalid University · SAJazan University · SAImam Abdulrahman Bin Faisal University · SA

Funding

King Khalid University RGP.1/336/42
6 · The paper itself

Abstract

There are more than 30 species of Glycyrrhiza genus extensively spread worldwide. It was the most prescribed herb in Ancient Egyptian, Roman, Greek, East China, and the West from the Former Han era. There are various beneficial effects of licorice root extracts, such as treating throat infections, tuberculosis, respiratory, liver diseases, antibacterial, anti-inflammatory, and immunodeficiency. On the other hand, traditional medicines are getting the attraction to treat many diseases. Therefore, it is vital to screen the medicinal plants to find the potential of new compounds to treat chronic diseases such as respiratory, cardiovascular, anticancer, hepatoprotective, etc. This work comprehensively reviews ethnopharmacological uses, phytochemistry, biological activities, clinical evidence, and the toxicology of licorice, which will serve as a resource for future clinical and fundamental studies. An attempt has been made to establish the pharmacological effect of licorice in different diseases. In addition, the focus of this review article is on the molecular mechanism of licorice extracts and their four flavonoids (isoliquiritigenin, liquiritigenin, lichalocone, and glabridin) pharmacologic activities. Licorice could be a natural alternative for current therapy to exterminate new emerging disorders with mild side effects. This review will provide systematic insights into this ancient drug for further development and clinical use.

Indexed as

anticancercardiovascularGlycyrrhiza glabrahepatoprotectivephytochemistryrespiratory infection

Identifiers

PMID34961221
PMCPMC8703329
OpenAlexW4200277291

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.