Evidence map›Paper›PMID 34961785›Full record

ReviewPediatric research2022

Neonates and COVID-19: state of the art : Neonatal Sepsis series.

L Ryan, Frans B Plötz, Agnes van den Hoogen, Jos M Latour, Marina Degtyareva, Maya Keuning, Claus Klingenberg, Irwin K M Reiss, Eric Giannoni, Charles Roehr and 2 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 7 countries.

L RyanNeonatology, CHI at Crumlin, Dublin, Ireland.
Frans B PlötzDepartment of Paediatrics, Tergooi Hospital, Blaricum, The Netherlands.
Agnes van den HoogenDivision Woman and Baby, Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht & Utrecht University, Utrecht, The Netherlands.
Jos M LatourSchool of Nursing and Midwifery, Faculty of Health, University of Plymouth, Plymouth, UK.
Marina DegtyarevaDepartment of Neonatology, Pirogov Russian National Research Medical University, Moscow, Russia.
Maya KeuningDepartment of Paediatrics, Amsterdam UMC, University of Amsterdam, Emma Children's Hospital, Amsterdam, The Netherlands.
Claus KlingenbergDepartment of Pediatrics and Adolescence Medicine, University Hospital of North Norway, Tromsø, Norway.
Irwin K M ReissDepartment of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
Eric GiannoniNeonatology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Charles RoehrNational Perinatal Epidemiology Unit, Clinical Trials Unit, Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, UK.
Christopher GaleNeonatal Medicine, School of Public Health, Faculty of Medicine, Chelsea and Westminster Campus, Imperial College London, London, UK.
Eleanor J MolloyNeonatology, CHI at Crumlin, Dublin, Ireland. Eleanor.molloy@tcd.ie.ORCID http://orcid.org/0000-0001-6798-2158
Emma Kinderziekenhuis · NLChildren's Health Ireland at Crumlin · IEErasmus MC - Sophia Children’s Hospital · NLImperial College London · GBPirogov Russian National Research Medical University · RUTrinity College · CAUniversity Hospital of North Norway · NOUniversity of Lausanne · CHUniversity of Oxford · GBUniversity of Plymouth · GBUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SARS-CoV-2 pandemic has had a significant impact worldwide, particularly in middle- and low-income countries. While this impact has been well-recognized in certain age groups, the effects, both direct and indirect, on the neonatal population remain largely unknown. There are placental changes associated, though the contributions to maternal and fetal illness have not been fully determined. The rate of premature delivery has increased and SARS-CoV-2 infection is proportionately higher in premature neonates, which appears to be related to premature delivery for maternal reasons rather than an increase in spontaneous preterm labor. There is much room for expansion, including long-term data on outcomes for affected babies. Though uncommon, there has been evidence of adverse events in neonates, including Multisystem Inflammatory Syndrome in Children, associated with COVID-19 (MIS-C). There are recommendations for reduction of viral transmission to neonates, though more research is required to determine the role of passive immunization of the fetus via maternal vaccination. There is now considerable evidence suggesting that the severe visitation restrictions implemented early in the pandemic have negatively impacted the care of the neonate and the experiences of both parents and healthcare professionals alike. Ongoing collaboration is required to determine the full impact, and guidelines for future management. IMPACT: Comprehensive review of current available evidence related to impact of the COVID-19 pandemic on neonates, effects on their health, impact on their quality of care and indirect influences on their clinical course, including comparisons with other age groups. Reference to current evidence for maternal experience of infection and how it impacts the fetus and then neonate. Outline of the need for ongoing research, including specific areas in which there are significant gaps in knowledge.

Indexed as

Infant, Newborn, DiseasesCOVID-19FemaleHumansInfant, NewbornInfectious Disease Transmission, VerticalMaternal-Fetal ExchangePlacentaPregnancyPremature BirthSARS-CoV-2Systemic Inflammatory Response Syndrome

Identifiers

PMID34961785
PMCPMC8712275
OpenAlexW4200571447

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.