Evidence map›Paper›PMID 34964890›Full record

Trial reportThe Journal of nutrition2022

Multivitamin Supplementation Is Associated with Greater Adequacy of Gestational Weight Gain among Pregnant Women in Tanzania.

Enju Liu, Dongqing Wang, Anne Marie Darling, Nandita Perumal, Molin Wang, Willy Urassa, Andrea Pembe, Wafaie W Fawzi

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00197548 (A Trial of Micronutrients and Adverse Pregnancy Outcomes), which is not on this map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00197548 phase3completednot on this map

A Trial of Micronutrients and Adverse Pregnancy Outcomes

TypeinterventionalSponsorHarvard School of Public Health (HSPH)Ran2001 to 2006Enrolled8,468ConditionsPregnancy, Premature Birth, Infant, Low Birth Weight, Pregnancy OutcomesArmsMultivitamins-vitamins B-complex, C, and E, Placebo
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Prenatal multiple micronutrient supplementation is associated with improved maternal gestational weight gain: A prospective longitudinal study in Parepare, Indonesia.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Enju LiuInstitutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, MA, USA.
Dongqing WangDepartment of Global Health and Population, Harvard TH Chan School of Public Health, Harvard University, Boston, MA, USA.
Anne Marie DarlingDepartment of Global Health and Population, Harvard TH Chan School of Public Health, Harvard University, Boston, MA, USA.
Nandita PerumalDepartment of Global Health and Population, Harvard TH Chan School of Public Health, Harvard University, Boston, MA, USA.ORCID 0000-0003-3624-4405
Molin WangDepartment of Epidemiology, Harvard TH Chan School of Public Health, Harvard University, Boston, MA, USA.
Willy UrassaDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Andrea PembeDepartment of Obstetrics and Gynaecology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Wafaie W FawziDepartment of Global Health and Population, Harvard TH Chan School of Public Health, Harvard University, Boston, MA, USA.
Harvard University · USMuhimbili University of Health and Allied Sciences · TZBoston Children's Hospital · US

Funding

Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD R01 37701
6 · The paper itself

Abstract

backgroundGestational weight gain (GWG) is a modifiable risk factor associated with adverse birth outcomes. Studies have shown that the provision of multiple micronutrient supplements to pregnant women reduces the risk of low birth weight. However, the effect of multiple micronutrient supplements on GWG has been understudied.

objectivesWe examined the effect of daily supplementation of pregnant women with multivitamins on GWG in relation to the GWG recommendation by the Institute of Medicine (IOM).

methodsPregnant women with gestational age between 12 and 27 wk were randomly assigned to receive daily multivitamins or placebo until delivery. Weight was measured at enrollment and every follow-up visit. Percentage adequacy of GWG was calculated as actual GWG divided by the recommended GWG according to the IOM recommendation. Binary outcomes included severely inadequate (<70%), inadequate (<90%), and excessive GWG (≥125%). The analysis included 7573 women with singleton pregnancies. Multiple linear regression models were used to examine the association between multivitamin supplementation and percentage adequacy of GWG, and log-binomial models were used for binary outcomes.

resultsThe mean percentage adequacy of GWG was 96.7% in the multivitamin arm and 94.4% in the placebo arm, with a mean difference of 2.3% (95% CI: 0.3%, 4.2%; P = 0.022). Compared with women in the placebo arm, those who received multivitamins had a lower risk of severely inadequate GWG (RR: 0.90; 95% CI: 0.83, 0.97; P = 0.008) and inadequate GWG (RR: 0.95; 95% CI: 0.91, 0.99; P = 0.018). No significant difference was found in excessive GWG.

conclusionsMultivitamin supplementation increased GWG and reduced the risk of severely inadequate and inadequate GWG among pregnant women in Tanzania. Together with previously reported beneficial effects of the supplements on birth outcomes in low- and middle-income countries, our findings support scaling up the use of prenatal supplements that include multivitamins in addition to iron and folic acid.This trial was registered at clinicaltrials.gov as NCT00197548.

Indexed as

Gestational Weight GainAdolescentAdultBody Mass IndexChildDietary SupplementsFemaleHumansPregnancyPregnancy OutcomePregnant PeopleTanzaniaVitaminsYoung AdultVitaminsbody mass indexgestational weight gainInstitute of Medicineprenatal multivitamin supplementationTanzania

Identifiers

PMID34964890
PMCPMC8970983
OpenAlexW4200317816

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.