Evidence map›Paper›PMID 34965971›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Mlc1-Expressing Perivascular Astrocytes Promote Blood-Brain Barrier Integrity.

John E Morales, Arpan De, Alexandra A Miller, Zhihua Chen, Joseph H McCarty

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 31 citations in OpenAlex.

  1. Cell-to-Cell Signaling Networks at the Blood-Brain Barrier in Health and Disease.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  2. Article
  3. Article
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  9. Article
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  11. Modulator of VRAC Current 1 Is a Potential Target Antigen in Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2025
    Article
  12. Review
  13. μ-Opioid Receptor Modulation of the Glutamatergic/GABAergic Midbrain Inputs to the Mouse Dorsal Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  14. Article
  15. Review
  16. Article
  17. Glial Cell Adhesion Molecule (GlialCAM) Determines Proliferative versus Invasive Cell States in Glioblastoma.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  18. Article
  19. Article
  20. Life (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

John E MoralesDepartment of Neurosurgery and Brain Tumor Center, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030.
Arpan DeDepartment of Neurosurgery and Brain Tumor Center, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030.ORCID 0000-0001-8237-6703
Alexandra A MillerDepartment of Neurosurgery and Brain Tumor Center, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030.ORCID 0000-0001-6748-0983
Zhihua ChenDepartment of Neurosurgery and Brain Tumor Center, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030.
Joseph H McCartyDepartment of Neurosurgery and Brain Tumor Center, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030 jhmccarty@mdanderson.org.
The University of Texas MD Anderson Cancer Center · US

Funding

Tropism Enhanced Oncolytic Adenovirus for the Treatment of Brain TumorsP50CA127001 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Juan Fueyo, FREDERICK F LANG · 2008 to 2026
$41.2M
Signal Transduction by alphaVbeta8 IntegrinR01NS087635 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MCCARTY, JOSEPH H · 2014 to 2024
$3.7M
Analyzing Cell-Cell Fusion in Glioblastoma Growth and ProgressionR21NS103841 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MCCARTY, JOSEPH H · 2019 to 2020
$440k
NCI NIH HHS P50 CA127001NINDS NIH HHS R01 NS087635NINDS NIH HHS R21 NS103841
6 · The paper itself

Abstract

In the mammalian brain, perivascular astrocytes (PAs) closely juxtapose blood vessels and are postulated to have important roles in the control of vascular physiology, including regulation of the blood-brain barrier (BBB). Deciphering specific functions for PAs in BBB biology, however, has been limited by the ability to distinguish these cells from other astrocyte populations. In order to characterize selective roles for PAs

Indexed as

AstrocytesHereditary Central Nervous System Demyelinating DiseasesAnimalsBlood-Brain BarrierBrainClaudin-5CystsDisease Models, AnimalMammalsMembrane ProteinsMiceClaudin-5Membrane ProteinsMlc1 protein, mouseangiogenesisendothelial celljuxtavascularmegalencephalic leukoencephalopathy with subcortical cysts 1microenvironmentneurovascular

Identifiers

PMID34965971
PMCPMC8883848
OpenAlexW4200440114

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.