ArticleAsian Pacific journal of cancer prevention : APJCP2021
The Role of hsa-miR-21 and Its Target Genes Involved in Nasopharyngeal Carcinoma.
Article in Asian Pacific journal of cancer prevention : APJCP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Integrative transcriptomic analysis identifies ACP5 and FBLN5 as candidate shared transcriptomic signatures between pulpitis and carotid plaque rupture.Scientific reports · 2026Article
- Integrative Bioinformatics Analysis of hsa-miR-21 in Breast Cancer Reveals a Prognostic Hub-Gene Signature.International journal of molecular sciences · 2026Article
- Multi-Level Profiling of MAPK-Associated Genes and MicroRNAs Uncovers Regulatory Networks in Breast Cancer Subtypes.International journal of molecular sciences · 2025Article
- hsa-miR-21-5p can serve as a standard biomarker in clear cell renal cell carcinoma by promoting tumor progression and influencing immune evasion.Discover oncology · 2025Article
- Trajectories and influencing factors of psychological distress in nasopharyngeal carcinoma patients receiving radiotherapy (incorporating genetic factors): a multicenter longitudinal study.Frontiers in oncology · 2025Article
- Comment on "The Diagnostic and Prognostic Value of miR‑155 in Cancers: An Updated Meta‑analysis".Molecular diagnosis & therapy · 2024Article
- Article
- Potential mechanisms and drug prediction of Rheumatoid Arthritis and primary Sjögren's Syndrome: A public databases-based study.PloS one · 2024Article
- Equine mesenchymal stem cell derived extracellular vesicle immunopathology biomarker discovery.Journal of extracellular biology · 2023Article
- Comprehensive Analysis of Transcriptional Expression of hsa-mir-21 Predicted Target Genes and Immune Characteristics in Kidney Renal Clear Cell Carcinoma.International journal of medical sciences · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMicroRNAs (miRNAs) are key post-transcriptional regulators of protein translation in humans. They have an essential role in various cancers, including nasopharyngeal carcinoma (NPC). The abnormal expression of miR-21 has been proven to be associated with various types of cancers, including NPC, through its targets. This study provides a systematic view of the roles of miR-21 and its network of targets (hsa-miR-21-3p, hsa-miR-21-5p) that are associated with nasopharyngeal carcinoma.
methodsBioinformatics tools were applied to predict the targets of miR-21. Interactions among the targets of hsa-miR-21-3p/5p were found by the gene MANIA online tool. RESULTS AND
conclusionIt was found that the target genes are involved in vital biological processes in cancer. In detail, a total of 95 targets of miR-21 were recorded to be associated with NPC. Therefore, they may provide new insights into nasopharyngeal pathogenesis and bring about novel targets for NPC diagnosis as well as therapy in near future.
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