Evidence map›Paper›PMID 34969265›Full record

ArticleThyroid : official journal of the American Thyroid Association2022

Severe Resistance to Thyroid Hormone Beta in a Patient with Athyreosis.

Federico Salas-Lucia, Monica M França, James A Amrhein, J Elizabeth Weir, Alexandra M Dumitrescu, Samuel Refetoff

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Thyroid : official journal of the American Thyroid Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Approach to the Patient With Raised Thyroid Hormones and Nonsuppressed TSH.The Journal of clinical endocrinology and metabolism · 2024
    Article
  4. ConcurrentClinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2024
    Article
  5. Effect of the Fetal THRB Genotype on the Placenta.The Journal of clinical endocrinology and metabolism · 2023
    Article
  6. Article
  7. Primary hypothyroidism and quality of life.Nature reviews. Endocrinology · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Federico Salas-LuciaDepartment of Medicine, The University of Chicago, Chicago, Illinois, USA.
Monica M FrançaDepartment of Medicine, The University of Chicago, Chicago, Illinois, USA.
James A AmrheinUSC School of Medicine Greenville Campus Pediatric Endocrinology and Diabetes, Prisma Health-Upstate, Greenville, South Carolina, USA.
J Elizabeth WeirUSC School of Medicine Greenville Campus Pediatric Endocrinology and Diabetes, Prisma Health-Upstate, Greenville, South Carolina, USA.
Alexandra M DumitrescuDepartment of Medicine, The University of Chicago, Chicago, Illinois, USA.ORCID 0000-0002-2743-770X
Samuel RefetoffDepartment of Medicine, The University of Chicago, Chicago, Illinois, USA.ORCID 0000-0003-0164-8231
University of Chicago · USPrisma Health · US

Funding

THYROID PHYSIOLOGY STUDIES OF INHERITED DISORDERSR01DK015070 · NIDDK · UNIVERSITY OF CHICAGO · PI ANTONIO C BIANCO, Alexandra Mihaela Dumitrescu · 1986 to 2026
$8.1M
NIDDK NIH HHS R01 DK015070
6 · The paper itself

Abstract

We report a patient with congenital hypothyroidism due to athyreosis complicated by a heterozygous thyroid hormone receptor beta (

Indexed as

Congenital HypothyroidismThyroid DysgenesisThyroid Hormone Resistance SyndromeHumansMutationThyroid Hormone Receptors betaThyroid HormonesThyrotropinThyroxineThyroid Hormone Receptors betaThyroid HormonesThyrotropinThyroxineathyreosiscongenital hypothyroidismlevothyroxine treatmentmutationresistance to thyroid hormone

Identifiers

PMID34969265
PMCPMC8971974
OpenAlexW4205393996

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.