Evidence map›Paper›PMID 34970748›Full record

ArticleMuscle & nerve2022

Risk factors for lumbosacral radiculoplexus neuropathy.

Marcus V Pinto, Peng-Soon Ng, Ruple S Laughlin, Prabin Thapa, Catarina Aragon Pinto, Shahar Shelly, Kamal Shouman, Peter J Dyck, P James B Dyck

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Muscle & nerve, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07646379 (Effects of Spinal Mobilization With Leg Movement With and Without Neural Flossing Technique on Pain, Disability, and Range of Motion in Patients With Lumbar Radiculopathy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07646379 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Spinal Mobilization With Leg Movement With and Without Neural Flossing Technique on Pain, Disability, and Range of Motion in Patients With Lumbar Radiculopathy

TypeinterventionalSponsorRiphah International UniversityRan2026 to 2026Enrolled36ConditionsLumbar RadiculopathyArmsSMWLM along with Neural flossing technique, SMWLM without Neural flossing technique
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Marcus V PintoDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-9890-6657
Peng-Soon NgDepartment of Neurology, National Neuroscience Institute, Singapore.
Ruple S LaughlinDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Prabin ThapaDepartment of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA.
Catarina Aragon PintoDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Shahar ShellyDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-3585-1687
Kamal ShoumanDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-0626-4835
Peter J DyckDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
P James B DyckDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-0212-8254
Mayo Clinic · USNational Neuroscience Institute · SG

Funding

NIA NIH HHS R01 AG034676NIA NIH HHS R01AG034676NIA NIH HHS R33 AG058738
6 · The paper itself

Abstract

INTRODUCTION/

aimsRecently, our group found an association between diabetes mellitus (DM) and lumbosacral radiculoplexus neuropathy (LRPN) in Olmsted County, Minnesota; we found a higher risk (odds ratio [OR], 7.91) for developing LRPN in diabetic compared with nondiabetic patients. However, the influence of other comorbidities and anthropomorphic variables was not studied.

methodsDemographic and clinical data from 59 LRPN patients and 177 age/sex-matched controls were extracted using the Rochester LRPN epidemiological study. Differences between groups were compared by chi-square/Fisher exact test or Wilcoxon rank-sum test. Uni- and multivariate logistic regression analysis were performed.

resultsFactors predictive of LRPN on univariate analysis were DM (OR, 7.91; 95% confidence interval [CI], 4.11-15.21), dementia (OR, 6.36; 95% CI, 1.13-35.67), stroke (OR, 3.81; 95% CI, 1.32-11.01), dyslipidemia (OR, 2.844; 95% CI, 1.53-5.27), comorbid autoimmune disorders (OR, 2.72; 95% CI, 1.07-6.93), hypertension (OR, 2.25; 95% CI, 1.2-4.13), obesity (OR, 2.05; 95% CI, 1.11-3.8), body mass index (BMI) (OR, 1.1; 95% CI, 1.04-1.15), and weight (OR, 1.02; 95% CI, 1.009-1.037). On multivariate logistic regression analysis only DM (OR, 8.03; 95% CI, 3.86-16.7), comorbid autoimmune disorders (OR, 4.58; 95% CI, 1.45-14.7), stroke (OR, 4.13; 95% CI, 1.2-14.25), and BMI (OR, 1.07; 95% CI, 1.01-1.13) were risk factors for LRPN. DISCUSSION: DM is the strongest risk factor for the development of LRPN, followed by comorbid autoimmune disorders, stroke, and higher BMI. Altered metabolism and immune dysfunction seem to be the most influential factors in the development of LRPN.

Indexed as

Autoimmune DiseasesDiabetic NeuropathiesStrokeHumansLumbosacral PlexusRisk Factorsdiabetes mellituslumbosacral plexopathylumbosacral radiculoplexus neuropathyvasculitis

Identifiers

PMID34970748
PMCPMC9181981
OpenAlexW4205096388

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.