Observational studyJournal of cardiology2022

The association of statins use with survival of patients with COVID-19.

Toshiki Kuno et al.PubMed ↗Full text ↗Publisher ↗

Continuous use of statinslooks good hereFewer in-hospital deaths.Correlation only, not a test of it.
Statin use prior to or during hospitalizationno clear effectNo clear link with in-hospital deaths.Correlation only, not a test of it.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Continuous use of statins went with fewer in-hospital deaths

−47%−59% to −32%

continuous use of statins vs discontinuation of statins

Bigger than 9 in 10 for all-cause mortality

As reported

OR 0.53, 95% CI 0.41–0.68 · the paper's word: in-hospital mortality

Correlation · may be no link

No clear link with in-hospital deaths

−4%−19% to +12%

statin use prior to or during hospitalization vs no statins

Bigger than 2 in 10 for all-cause mortality

As reported

OR 0.96, 95% CI 0.81–1.12 · the paper's word: in-hospital mortality

Correlation, not cause

Continuous use of statins went with fewer in-hospital deaths

−32%−45% to −18%

continuous use of statins vs no statins group

Bigger than 8 in 10 for all-cause mortality

As reported

OR 0.68, 95% CI 0.55–0.82 · the paper's word: in-hospital mortality

+2 more in the walkthrough ↓

Who was studied, and how

6,095people with dyslipidemia, in this paper

Already taking continuous use of statins, or nottheir own situation, not assigned

on continuous use of statins

discontinuation of statins

Continuous use of statins went with fewer in-hospital deaths−47%

correlation, not a test

Already taking statin use prior to or during hospitalization, or nottheir own situation, not assigned

on statin use prior to or during hospitalization

not on statins

No clear link with in-hospital deaths−4%

correlation, not a test

the abstract, start to end

… versus 42.1%, p<0.001, OR (95% CI): 0.53 (0.41-0.68)].

… confirmed by IPTW analysis [OR (95% CI): 0.96 (0.81-1.12), p = 0.53].

… versus 34.5%, p<0.001, OR (95% CI): 0.68 (0.55-0.82)] after matching by propensity score (944 pairs), as well as IPTW analysis [OR (95% CI): 0.77 (0.64-0.94), p = 0.009].

… ratio (OR) 95% confidence interval (CI): 0.91 (0.79-1.05)].

← favours treatmentfavours comparator →

could be chance

In-hospital mortalitycontinuous use of statins vs discontinuation of statins

OR 0.530.41–0.68

In-hospital mortalitystatin use prior to or during hospitalization vs no statins

OR 0.960.81–1.12

In-hospital mortalitycontinuous use of statins vs no statins group

OR 0.680.55–0.82

In-hospital mortalitystatin use prior to or during hospitalization vs no statins

OR 0.910.79–1.05

In-hospital mortalitycontinuous use of statins vs no statins group

OR 0.770.64–0.94

StatinsAll-cause mortality

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14 papers cite it

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this papertrialcites it

The association of statins use with survival of patients with COVID-19.

What moved togetherboth groups pooled, not the treatment’s effect

Continuous use of statins went with fewer in-hospital deaths

No clear link with in-hospital deaths

Continuous use of statins went with fewer in-hospital deaths

Who was studied, and how

Five numbers in the abstract

Where each one falls

Where it lands on the map

14 papers cite it