ReviewFrontiers in immunology2021
Gut Immune System and the Implications of Oral-Administered Immunoprophylaxis in Finfish Aquaculture.
Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Gut Microbiome of Aquatic Organisms: Role in Immunity Formation and Effects on Aquaculture Productivity.Microorganisms · 2026Review
- Metabolomic Profiling Reveals Intestinal Metabolic Reprogramming in Chinese Tongue Sole (Animals : an open access journal from MDPI · 2026Article
- Application of antimicrobial peptides expressed by Tetraselmis subcordiformis (Wille) butcher improves the health of turbot via oral administration.World journal of microbiology & biotechnology · 2026Article
- Teleost intestinal microfold cells: identification, characterization, and mucosal antigen sampling in olive flounder (Marine life science & technology · 2026Article
- Review
- p53 regulates early mucosal immunity via antigen presentation in zebrafish intestine post-SVCV vaccination.Cell communication and signaling : CCS · 2026Article
- Comparative gut microbiome analysis of Rohu fish from Halda River and Kaptai Lake using 16S rRNA sequencing.Scientific reports · 2026Article
- A bivalent oral yeast vaccine displayingFrontiers in immunology · 2026Article
- Mushroom stem-based diets elicit region-specific shifts in rainbow trout gut microbiota.Scientific reports · 2025Article
- Gut dysbiosis after successive administration of florfenicol-medicated feed alters intestinal inflammatory response and growth patterns in healthy Atlantic salmon (Salmo salar).Animal microbiome · 2025Article
- Whole-Genome-Sequencing Analysis of the Pathogen Causing Spotting Disease and Molecular Response in theMicroorganisms · 2025Article
- Characteristics and Functions of Different Intestinal Segments in Juvenile Greater Amberjack (Animals : an open access journal from MDPI · 2025Article
- Article
- An experimental study of levamisole incorporated diet on fish health and resistance against Pseudomonas aeruginosa isolated from Oreochromas niloticus.Scientific reports · 2025Article
- Impact of Dietary Feeding Levels of Juvenile Red-Tail Catfish (Aquaculture nutrition · 2025Article
- TransgenicMarine drugs · 2024Article
- Mannose and Lactobionic Acid in Nasal Vaccination: Enhancing Antigen Delivery via C-Type Lectin Receptors.Pharmaceutics · 2024Review
- Article
- The effects ofFrontiers in immunology · 2024Article
- Editorial: Chrono-immunonutrition in aquaculture towards robust and resilient fish.Frontiers in immunology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gastrointestinal immune system plays an important role in immune homeostasis regulation. It regulates the symbiotic host-microbiome interactions by training and developing the host's innate and adaptive immunity. This interaction plays a vital role in host defence mechanisms and at the same time, balancing the endogenous perturbations of the host immune homeostasis. The fish gastrointestinal immune system is armed with intricate diffused gut-associated lymphoid tissues (GALTs) that establish tolerance toward the enormous commensal gut microbiome while preserving immune responses against the intrusion of enteric pathogens. A comprehensive understanding of the intestinal immune system is a prerequisite for developing an oral vaccine and immunostimulants in aquaculture, particularly in cultured fish species. In this review, we outline the remarkable features of gut immunity and the essential components of gut-associated lymphoid tissue. The mechanistic principles underlying the antigen absorption and uptake through the intestinal epithelial, and the subsequent immune activation through a series of molecular events are reviewed. The emphasis is on the significance of gut immunity in oral administration of immunoprophylactics, and the different potential adjuvants that circumvent intestinal immune tolerance. Comprehension of the intestinal immune system is pivotal for developing effective fish vaccines that can be delivered orally, which is less labour-intensive and could improve fish health and facilitate disease management in the aquaculture industry.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.