Evidence map›Paper›PMID 34976467›Full record

ReviewCureus2021

Beyond the Skin Plaques: Psoriasis and Its Cardiovascular Comorbidities.

Chandra L Kakarala, Mohammad Hassan, Rishab Belavadi, Sri Vallabh Reddy Gudigopuram, Ciri C Raguthu, Harini Gajjela, Iljena Kela, Ibrahim Sange

Abstract readReview
In one paragraph

Review in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chandra L KakaralaInternal Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, IND.
Mohammad HassanInternal Medicine, Mohi-ud-Din Islamic Medical College, Mirpur, PAK.
Rishab BelavadiSurgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, IND.
Sri Vallabh Reddy GudigopuramResearch, Our Lady of Fatima University College of Medicine, Hyderabad, IND.
Ciri C RaguthuResearch, Tianjin Medical University, Tianjin, CHN.
Harini GajjelaResearch, Our Lady of Fatima University College of Medicine, Valenzuela, PHL.
Iljena KelaFamily Medicine, Jagiellonian University Medical College, Krakow, POL.
Ibrahim SangeResearch, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis, a widely prevalent chronic disease of the skin and joints, has long been associated with far-reaching systemic ramifications and decreased quality of life. However, psoriasis is largely underdiagnosed and insufficiently treated. Classical risk factors predisposing to cardiovascular diseases, such as hypertension, diabetes, metabolic syndrome, and dyslipidemia, have been noted in patients with mild and severe psoriasis. Furthermore, the magnitude of the cardiovascular comorbidity and the need to screen for risk factors has often been ignored while considering the management options for psoriasis. This article has reviewed the cardiovascular implications of psoriasis from the shared pathogenesis behind these two diseases to the increased incidence of cardiovascular events, such as myocardial infarction, stroke, and other causes of vascular mortality. Additionally, the therapeutic targets of common inflammatory pathways, such as those involving tumor necrosis factor α (TNF-α), interleukin-12/interleukin-23 (IL-12/IL-23), and helper T cells 17 (Th17), have been discussed with an emphasis on their efficacy in controlling psoriasis and its cardiovascular consequences.

Indexed as

anti-il12/23anti-tumor-necrosis factor-alphacardiovascular diseasecardiovascular riskpsoriasissystemic inflammation

Identifiers

PMID34976467
PMCPMC8683276

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.