Evidence map›Paper›PMID 34977959›Full record

SynthesisEuropean journal of nutrition2022

Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials.

Erand Llanaj, Gordana M Dejanovic, Ezra Valido, Arjola Bano, Magda Gamba, Lum Kastrati, Beatrice Minder, Stevan Stojic, Trudy Voortman, Pedro Marques-Vidal and 5 more

Registry-linked trialOpen access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07371598 (Impact of Royal Ancient Oats™ on Glycemic Response and Digestive Enzymes), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07371598 narecruitingnot on this mapstarted 2026, after this paper: background citation

Impact of Royal Ancient Oats™ on Glycemic Response and Digestive Enzymes

TypeinterventionalSponsorStandard Process Inc.Ran2026 to 2026Enrolled38ConditionsHealthy Participants, Healthy GlucoseArmsRoyal Ancient Oat Flour™
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

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  7. Article
  8. Assessment of ImmobilizedFoods (Basel, Switzerland) · 2024
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  16. The Adapted POM Analysis of Avenanthramides In Silico.Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 5 countries.

Erand Llanaj *Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Gordana M Dejanovic *Department of Ophthalmology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Ezra ValidoSwiss Paraplegic Research, Nottwil, Switzerland.
Arjola BanoInstitute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
Magda GambaInstitute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
Lum KastratiFaculty of Medicine, University of Prishtina "Hasan Prishtina", Prishtina, Kosovo.
Beatrice MinderPublic Health and Primary Care Library, University Library of Bern, University of Bern, Bern, Switzerland.
Stevan StojicSwiss Paraplegic Research, Nottwil, Switzerland.
Trudy VoortmanDepartment of Epidemiology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Pedro Marques-VidalDepartment of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Jivko StoyanovSwiss Paraplegic Research, Nottwil, Switzerland.
Brandon MetzgerStandard Process Nutrition Innovation Centre, Kannapolis, USA.
Marija GlisicSwiss Paraplegic Research, Nottwil, Switzerland.
Hua Kern *Standard Process Nutrition Innovation Centre, Kannapolis, USA.
Taulant Muka *Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland. taulant.muka@ispm.unibe.ch.
University of Bern · CHSwiss Paraplegic Research · CHErasmus MC · NLInstitute of Social and Preventive Medicine · CHUniversity of Debrecen · HUUniversity of Lausanne · CHUniversity of Novi Sad · RSUniversity of Prishtina · XK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOat supplementation interventions (OSIs) may have a beneficial effect on cardiovascular disease (CVD) risk. However, dietary background can modulate such effect. This systematic review assesses the effects of OSIs on CVD risk markers among adults, accounting for different dietary backgrounds or control arms.

methodsWe included randomized clinical trials (RCTs) that assessed the effect of oat, oat beta-glucan-rich extracts or avenanthramides on CVD risk markers.

resultsSeventy-four RCTs, including 4937 predominantly hypercholesterolemic, obese subjects, with mild metabolic disturbances, were included in the systematic review. Of these, 59 RCTs contributed to the meta-analyses. Subjects receiving an OSI, compared to control arms without oats, had improved levels of total cholesterol (TC) [weighted mean difference and (95% CI) - 0.42 mmol/L, (- 0.61; - 0.22)], LDL cholesterol [- 0.29 mmol/L, (- 0.37; - 0.20)], glucose [- 0.25 nmol/L, (- 0.36; - 0.14)], body mass index [- 0.13 kg/m

conclusionDietary OSIs resulted in lowered levels of blood lipids and improvements in anthropometric parameters among participants with predominantly mild metabolic disturbances, regardless of dietary background or control. Further high-quality trials are warranted to establish the role of OSIs on blood pressure, glucose homeostasis and inflammation markers.

Indexed as

AvenaCardiovascular DiseasesAdultBiomarkersCholesterolDietary SupplementsGlucoseHumansInflammationRandomized Controlled Trials as TopicBiomarkersCholesterolGlucoseCardiovascular diseasesCholesterolInterventionsNutritionOatsRisk markersSupplementation

Identifiers

PMID34977959
PMCPMC9106631
OpenAlexW4206709747

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.