Evidence map›Paper›PMID 34979947›Full record

ArticleBMC geriatrics2022

Association between single nucleotide polymorphism of rs1937 in TFAM gene and longevity among the elderly Chinese population: based on the CLHLS study.

Qing Chen, Zhi-Hao Li, Wei-Qi Song, Yao Yao, Yu-Jie Zhang, Wen-Fang Zhong, Pei-Dong Zhang, Dan Liu, Xi-Ru Zhang, Qing-Mei Huang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Qing Chen *Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Zhi-Hao Li *Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
Wei-Qi Song *Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
Yao YaoCenter for Healthy Aging and Development Studies, National School of Development, Peking University, Beijing, China.
Yu-Jie ZhangDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
Wen-Fang ZhongDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
Pei-Dong ZhangDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
Dan LiuDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
Xi-Ru ZhangDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
Qing-Mei HuangDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
Xiao-Yang ZhaoState Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. zhaoxiaoyang@smu.edu.cn.
Xiao-Ming ShiNational Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China. shixm@chinacdc.cn.
Chen MaoDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China. maochen9@smu.edu.cn.
Southern Medical University · CNChinese Center For Disease Control and Prevention · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate whether the mitochondrial transcription factor A (TFAM) rs1937 single nucleotide polymorphism (SNP) is associated with longevity.

methodsWe conducted a case-control study among Chinese long-lived individuals (≥90 years). Data were obtained on 3294 participants who were able to voluntarily provided a saliva sample during 2008-2009 from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). In this study, 1387 young elderly (65-74 years) were allocated to the control group, and 1907 long-lived individuals were recruited as the case group. SNP rs1937 on TFAM were genotyped. Logistic regression models were applied to evaluate the association between rs1937 SNP and longevity.

resultsThe genotype frequency of the SNP of rs1937 in the two groups had a significant difference (p = 0.003). Binary logistic regression analysis showed that compared to younger elderly, the long-lived individuals with "CC genotype" of rs1937 were more closely related to increased longevity than those with "GG genotype" (OR: 1.989, 95% CI: 1.160-3.411). The positive association between rs1937 SNP and longevity was robust in stratified analyses and sensitivity analyses.

conclusionsWe found the SNP of rs1937 may be a potential biomarker for longer human life span. Further studies are necessary to elucidate the biological mechanism of rs1937 on TFAM with promoting longevity.

Indexed as

LongevityPolymorphism, Single NucleotideAdultAgedAsian PeopleCase-Control StudiesChinaDNA-Binding ProteinsGenotypeHumansMiddle AgedMitochondrial ProteinsTranscription FactorsDNA-Binding ProteinsMitochondrial ProteinsTFAM protein, humanTranscription FactorsLongevityLong-lived individualsrs1937Single nucleotide polymorphismTFAM

Identifiers

PMID34979947
PMCPMC8722189
OpenAlexW4206085925

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.