Evidence map›Paper›PMID 34985402›Full record

ArticleAmerican journal of respiratory and critical care medicine2022

Candidate Role for Toll-like Receptor 3 L412F Polymorphism and Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis.

Aoife N McElroy, Rachele Invernizzi, Joanna W Laskowska, Andrew O'Neill, Mohammad Doroudian, Mohsen Moghoofei, Shayan Mostafaei, Feng Li, Alexander A Przybylski, David N O'Dwyer and 8 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Immunosenescence in Idiopathic Pulmonary Fibrosis.Journal of inflammation research · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Persistent microbial infections and idiopathic pulmonary fibrosis - an insight intoFrontiers in cellular and infection microbiology · 2024
    Review
  15. Review
  16. Article
  17. Acute Exacerbations of Interstitial Lung Diseases: Focus on Biomarkers.International journal of molecular sciences · 2023
    Review
  18. Article
  19. Insights from Transcriptomics: CD163American journal of respiratory cell and molecular biology · 2022
    Review
  20. Identifying the Risk of Acute Exacerbation in Idiopathic Pulmonary Fibrosis: A Step Forward.American journal of respiratory and critical care medicine · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 4 countries.

Aoife N McElroySchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland.
Rachele InvernizziNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0002-6957-9626
Joanna W LaskowskaSchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland.
Andrew O'NeillSchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland.
Mohammad DoroudianDepartment of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.ORCID 0000-0002-2933-9898
Mohsen MoghoofeiInfectious Diseases Research Centre and.
Shayan MostafaeiDepartment of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Feng LiMRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Alexander A PrzybylskiMRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
David N O'DwyerDivision of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan.
Andrew G BowieSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, and.
Padraic G FallonSchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland.
Toby M MaherNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0001-7192-9149
Cory M HogaboamDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Philip L MolyneauxNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Nik HiraniMRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Michelle E ArmstrongSchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland.ORCID 0000-0001-7729-755X
Seamas C DonnellySchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland.ORCID 0000-0001-7145-1843
Trinity College Dublin · IEQueen's Medical Centre · GBRoyal Brompton Hospital · GBCedars-Sinai Medical Center · USEdinburgh Royal Infirmary · GBImperial College London · GBKermanshah University of Medical Sciences · IRKharazmi University · IRUniversity of Michigan · US

Funding

Innate DNA sensing in rapidly progressing IPFR01HL123899 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI HOGABOAM, CORY M · 2015 to 2018
$2.0M
Department of Health CS-2013-13-017HSRD VA CDA 13-017Medical Research Council G0701740Medical Research Council MR/K015206/1NHLBI NIH HHS R01 HL123899Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Idiopathic Pulmonary FibrosisAnti-Bacterial AgentsAntiviral AgentsDisease ProgressionHumansRNA, Ribosomal, 16SToll-Like Receptor 3Anti-Bacterial AgentsAntiviral AgentsRNA, Ribosomal, 16STLR3 protein, humanToll-Like Receptor 3acute exacerbationsidiopathic pulmonary fibrosislung microbiomeTLR3 L412Fviral and bacterial coinfection

Identifiers

PMID34985402
PMCPMC12042197
OpenAlexW4205328813

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.