ArticleMethods in molecular biology (Clifton, N.J.)2022
Experimental Models to Study HIV Latency Reversal from Male Genital Myeloid Cells.
Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- HIV-1 Myeloid Reservoirs - Contributors to Viral Persistence and Pathogenesis.Current HIV/AIDS reports · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HIV reservoirs in tissues are poorly understood and their establishment largely depends on the nature of tissues that interact with the virus. In this chapter, we will describe in vitro and ex vivo models of human urethral mucosal macrophages used in the investigation of the establishment and maintenance of tissue HIV reservoirs. In addition, we will describe how macrophage latent HIV infection was assessed in these models by reverting a nonproductive state of infection back into a productive state. Consequently, infectious particles are released to the macrophage extracellular milieu and detected by adapted viral outgrowth assays. Altogether, these approaches provide invaluable tools for the investigation on tissue-specific pathways that HIV-1 employs to reach host cells and form reservoirs in the genital mucosa. These models will contribute to the development of an efficient and targeted prophylaxis against HIV and of a HIV cure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.