Evidence map›Paper›PMID 34985688›Full record

SynthesisInfection2022

Body mass index and risk of clostridioides difficile infection: a systematic review and meta-analysis.

Nipith Charoenngam, Ben Ponvilawan, Jerapas Thongpiya, Pitchaporn Yingchoncharoen, Thanat Chaikijurajai, Natapat Chaisidhivej, Caroline M Apovian, Patompong Ungprasert

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Infection, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. The Impact of Obesity onJournal of clinical medicine · 2025
    Article
  2. Clinical microbiology reviews · 2024
    Review
  3. Article
  4. Article
  5. Geriatric nutritional risk index as a risk-factor forJournal of rural medicine : JRM · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nipith CharoenngamDepartment of Medicine, Mount Auburn Hospital, Harvard Medical School, 330 Mt Auburn St, Cambridge, MA, 02138, USA. nipith.charoenngam@gmail.com.ORCID http://orcid.org/0000-0002-6501-6180
Ben PonvilawanDepartment of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Jerapas ThongpiyaDepartment of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Pitchaporn YingchoncharoenDepartment of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Thanat ChaikijurajaiDepartment of Medicine, University of Minnesota, Twin Cities, Minneapolis, MN, USA.
Natapat ChaisidhivejDepartment of Medicine, Einstein Medical Center Philadelphia, Philadelphia, PA, USA.
Caroline M ApovianSection of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Patompong UngprasertDepartment of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA.

Funding

SIGNAL TRANSDUCTION IN HUMAN ABDOMINAL AND GLUTEOFEMORAL ADIPOCYTESP30DK046200 · TUFTS MEDICAL CENTER · 1992 to 2005
$5.3M
NIDDK NIH HHS P30 DK046200
6 · The paper itself

Abstract

objectiveTo comprehensively investigate the association between obesity/high body mass index (BMI) and risk of Clostridioides difficile infection (CDI) using systematic review and meta-analysis.

methodsPotentially eligible studies were identified from Medline and EMBASE databases from inception to February 2021 using search strategy consisting of terms for "Body Mass Index" and "Clostridioides Difficile". We only included studies that consist of a group of individuals with CDI and another group without CDI. Then, the studies must report their BMI or history of obesity. Odds ratio (OR) and 95% CIs of the association between BMI status and CDI were retrieved from each study and combined using the generic inverse variance method. Funnel plot was used to assess publication bias.

resultsA total of 4609 articles were identified. After two rounds of systematic review, 17 studies met the eligibility criteria and were included into the meta-analysis. Pooled analysis showed that individuals with high BMI had a significantly decreased odds of CDI with the pooled OR of 0.88 (95% CI 0.80-0.97). This meta-analysis had high statistical heterogeneity with I

conclusionThis meta-analysis revealed a significant negative association between BMI and CDI.

Indexed as

Clostridium InfectionsBody Mass IndexHumansObesityOdds RatioBody mass indexClostridioides difficileClostridium difficileMeta-analysisSystematic review

Identifiers

PMID34985688

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.