Evidence map›Paper›PMID 34986021›Full record

ArticleAmerican journal of physiology. Cell physiology2022

Reducing sarcolipin expression improves muscle metabolism in

Rekha Balakrishnan, Satvik Mareedu, Gopal J Babu

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  8. BKPharmaceutics · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rekha BalakrishnanDepartment of Cell Biology and Molecular Medicine, Rutgers, New Jersey Medical School, Newark, New Jersey.ORCID 0000-0002-9724-5578
Satvik MareeduDepartment of Cell Biology and Molecular Medicine, Rutgers, New Jersey Medical School, Newark, New Jersey.
Gopal J BabuDepartment of Cell Biology and Molecular Medicine, Rutgers, New Jersey Medical School, Newark, New Jersey.ORCID 0000-0001-7833-5300
Rutgers, The State University of New Jersey · US

Funding

Sarcolipin in Duchenne Muscular DystrophyR01AR069107 · NIAMS · RBHS-NEW JERSEY MEDICAL SCHOOL · PI BABU, GOPAL JEGADEESH · 2016 to 2020
$1.7M
NIAMS NIH HHS R01 AR069107
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is an inherited muscle wasting disease. Metabolic impairments and oxidative stress are major secondary mechanisms that severely worsen muscle function in DMD. Here, we sought to determine whether germline reduction or ablation of sarcolipin (SLN), an inhibitor of sarco/endoplasmic reticulum (SR) Ca

Indexed as

AnimalsBlood GlucoseFemaleMaleMiceMice, Inbred C57BLMice, Inbred mdxMice, KnockoutMuscle ProteinsMuscle, SkeletalOxidative StressProteolipidsBlood GlucoseMuscle ProteinsProteolipidssarcolipinDuchenne muscular dystrophymdxmetabolismmitochondriasarcolipin

Identifiers

PMID34986021
PMCPMC8816636
OpenAlexW4205845726

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.