Evidence map›Paper›PMID 34986673›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022

Venous cerebral blood flow quantification and cognition in patients with sickle cell anemia.

Hanne Stotesbury, Patrick W Hales, Melanie Koelbel, Anna M Hood, Jamie M Kawadler, Dawn E Saunders, Sati Sahota, David C Rees, Olu Wilkey, Mark Layton and 6 more

Abstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Cerebral Blood Transit in Sickle Cell Anemia.Journal of magnetic resonance imaging : JMRI · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hanne StotesburyDevelopmental Neurosciences, UCL Great Ormond St. Institute of Child Health, London, UK.ORCID 0000-0003-0481-8259
Patrick W HalesDevelopmental Neurosciences, UCL Great Ormond St. Institute of Child Health, London, UK.
Melanie KoelbelDevelopmental Neurosciences, UCL Great Ormond St. Institute of Child Health, London, UK.ORCID 0000-0003-3672-7669
Anna M HoodDevelopmental Neurosciences, UCL Great Ormond St. Institute of Child Health, London, UK.ORCID 0000-0002-7213-1179
Jamie M KawadlerDevelopmental Neurosciences, UCL Great Ormond St. Institute of Child Health, London, UK.
Dawn E SaundersDivision of Psychology and Mental Health, Manchester Centre for Health Psychology, University of Manchester, Manchester, UK.
Sati SahotaDevelopmental Neurosciences, UCL Great Ormond St. Institute of Child Health, London, UK.
David C ReesRadiology, Great Ormond Hospital for Children NHS Trust, London, UK.
Olu WilkeyKing's College London, London, UK.
Mark LaytonNorth Middlesex University Hospital NHS Foundation Trust, London, UK.
Maria PelidisHaematology, Imperial College Healthcare NHS Foundation Trust, London, UK.
Baba Pd InusaHaematology, Imperial College Healthcare NHS Foundation Trust, London, UK.
Jo HowardHaematology, Imperial College Healthcare NHS Foundation Trust, London, UK.
Subarna ChakravortyRadiology, Great Ormond Hospital for Children NHS Trust, London, UK.
Chris A ClarkDevelopmental Neurosciences, UCL Great Ormond St. Institute of Child Health, London, UK.
Fenella J KirkhamDevelopmental Neurosciences, UCL Great Ormond St. Institute of Child Health, London, UK.

Funding

Asthma and Nocturnal Hypoxemia in Sickle Cell Anemia IIR01HL079937 · NHLBI · WASHINGTON UNIVERSITY · PI DEBAUN, MICHAEL R., STRUNK, ROBERT · 2005 to 2013
$10.4M
White Matter Structural Integrity and Cognition in Children with Sickle Cell DiseaseF32HL143915 · NHLBI · UNIVERSITY COLLEGE LONDON · PI HOOD, ANNA · 2018 to 2021
$167k
NHLBI NIH HHS F32 HL143915NHLBI NIH HHS R01 HL079937
6 · The paper itself

Abstract

Prior studies have described high venous signal qualitatively using arterial spin labelling (ASL) in patients with sickle cell anemia (SCA), consistent with arteriovenous shunting. We aimed to quantify the effect and explored cross-sectional associations with arterial oxygen content (CaO

Indexed as

Anemia, Sickle CellCerebrovascular CirculationCognitionCross-Sectional StudiesHumansMagnetic Resonance ImagingSpin LabelsSpin LabelsCerebrovascular diseasecognitionhematologyhemodynamicsMRI

Identifiers

PMID34986673
PMCPMC9121533

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.