SynthesisFrontiers in neuroscience2021
Detecting Noise-Induced Cochlear Synaptopathy by Auditory Brainstem Response in Tinnitus Patients With Normal Hearing Thresholds: A Meta-Analysis.
Synthesis in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Trends and mechanistic insights into hypertension-associated hearing loss: a 20-year perspective (2005-2025).Frontiers in molecular neuroscience · 2026Pooled it
- Brainstem evoked auditory potentials in tinnitus: A best-evidence synthesis and meta-analysis.Frontiers in neurology · 2022Pooled it
- Myofascial pain and dysfunction as predictors of tinnitus in adults: a case-control study.Head & face medicine · 2026Article
- Tinnitus.Nature reviews. Disease primers · 2026Review
- A delayed pharmacological treatment strategy attenuates noise-induced tinnitus in rats.Scientific reports · 2026Article
- Application of neurodegenerative disease treatment strategies in tinnitus: mechanisms, translation, and prospects.Frontiers in aging neuroscience · 2026Review
- Phase II Clinical Study on Low-Intensity-Noise Tinnitus Suppression (LINTS) for Tinnitus Treatment.Brain sciences · 2025Article
- Investigation of Listening Effort in Tinnitus Patients by Providing Similar Peripheral Auditory Function With Control Group.Brain and behavior · 2025Article
- Interplay between noise-induced sensorineural hearing loss and hypertension: pathophysiological mechanisms and therapeutic prospects.Frontiers in cellular neuroscience · 2025Review
- [Characteristics of the Hearing Curves in 672 Tinnitus Patients and Their Relationship With Tinnitus Treatment Outcomes].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Review
- Identifying Health-Related Conditions Associated with Tinnitus in Young Adults.Audiology research · 2023Article
- Influence of tinnitus, lifetime noise exposure, and firearm use on hearing thresholds, distortion product otoacoustic emissions, and their relative metric.The Journal of the Acoustical Society of America · 2023Article
- The middle ear muscle reflex: Current and future role in assessing noise-induced cochlear damage.The Journal of the Acoustical Society of America · 2023Article
- Noise-induced hearing disorders: Clinical and investigational tools.The Journal of the Acoustical Society of America · 2023Article
- Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R.Journal of visualized experiments : JoVE · 2022Article
- Tinnitus, sound intolerance, and mental health: the role of long-term occupational noise exposure.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Lower glutamate and GABA levels in auditory cortex of tinnitus patients: a 2D-JPRESS MR spectroscopy study.Scientific reports · 2022Article
- Audiological and psychological assessment of tinnitus patients with normal hearing.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noise-induced cochlear synaptopathy (CS) is defined as a permanent loss of synapses in the auditory nerve pathway following noise exposure. Several studies using auditory brainstem response (ABR) have indicated the presence of CS and increased central gain in tinnitus patients with normal hearing thresholds (TNHT), but the results were inconsistent. This meta-analysis aimed to review the evidence of CS and its pathological changes in the central auditory system in TNHT. Published studies using ABR to study TNHT were reviewed. PubMed, EMBASE, and Scopus databases were selected to search for relevant literature. Studies (489) were retrieved, and 11 were included for meta-analysis. The results supported significantly reduced wave I amplitude in TNHT, whereas the alternations in wave V amplitude were inconsistent among the studies. Consistently increased V/I ratio indicated noise-induced central gain enhancement. The results indicated the evidence of noise-induced cochlear synaptopathy in tinnitus patients with normal hearing. However, inconsistent changes in wave V amplitude may be explained by that the failure of central gain that triggers the pathological neural changes in the central auditory system and/or that increased central gain may be necessary to generate tinnitus but not to maintain tinnitus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.