ArticleFrontiers in human neuroscience2021
Theta Oscillations at Subthalamic Region Predicts Hypomania State After Deep Brain Stimulation in Parkinson's Disease.
Article in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Basal ganglia neurophysiological markers of non-motor symptoms in Parkinson's disease: A systematic review.Journal of Parkinson's disease · 2026Pooled it
- Effect of HD-tDCS targeting the DLPFC on cognitive ability and flight simulation performance in healthy adults.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Trial
- Novel predictors of postoperative delirium after awake subthalamic nucleus deep brain stimulation for Parkinson's disease.BMJ neurology open · 2026Article
- Subthalamic Theta-Alpha Local Field Potentials in OFF-Levodopa Dystonia in Parkinson's Disease.Movement disorders clinical practice · 2026Article
- Current and future applications of local field potential-guided programming for Parkinson's disease with the Percept™ rechargeable neurostimulator.Neurodegenerative disease management · 2024Review
- Subthalamic high-beta oscillation informs the outcome of deep brain stimulation in patients with Parkinson's disease.Frontiers in human neuroscience · 2022Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective treatment for the motor impairments of patients with advanced Parkinson's disease. However, mood or behavioral changes, such as mania, hypomania, and impulsive disorders, can occur postoperatively. It has been suggested that these symptoms are associated with the stimulation of the limbic subregion of the STN. Electrophysiological studies demonstrate that the low-frequency activities in ventral STN are modulated during emotional processing. In this study, we report 22 patients with Parkinson's disease who underwent STN DBS for treatment of motor impairment and presented stimulation-induced mood elevation during initial postoperative programming. The contact at which a euphoric state was elicited by stimulation was termed as the hypomania-inducing contact (HIC) and was further correlated with intraoperative local field potential recorded during the descending of DBS electrodes. The power of four frequency bands, namely, θ (4-7 Hz), α (7-10 Hz), β (13-35 Hz), and γ (40-60 Hz), were determined by a non-linear variation of the spectrogram using the concentration of frequency of time (conceFT). The depth of maximum θ power is located approximately 2 mm below HIC on average and has significant correlation with the location of contacts (
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