Evidence map›Paper›PMID 34987381›Full record

ReviewFrontiers in pharmacology2021

Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases.

Dan-Yang Ren, Xin-Rong Yuan, Cai-Xia Tu, Jian-Ling Shen, Yun-Wei Li, Ai-Hua Yan, Yi Ru, Hui-Yun Han, Yan-Ming Yang, Yan Liu and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. RNA Pol II Assembly Affects ncRNA Expression.International journal of molecular sciences · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Dan-Yang RenPharmaceutical Preparation Section, Children's Hospital of Kunming Medical University, Kunming, China.
Xin-Rong YuanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Cai-Xia TuPharmaceutical Preparation Section, Children's Hospital of Kunming Medical University, Kunming, China.
Jian-Ling ShenPharmaceutical Preparation Section, Children's Hospital of Kunming Medical University, Kunming, China.
Yun-Wei LiPharmaceutical Preparation Section, Children's Hospital of Kunming Medical University, Kunming, China.
Ai-Hua YanPharmaceutical Preparation Section, Children's Hospital of Kunming Medical University, Kunming, China.
Yi RuPharmaceutical Preparation Section, Children's Hospital of Kunming Medical University, Kunming, China.
Hui-Yun HanPharmaceutical Preparation Section, Children's Hospital of Kunming Medical University, Kunming, China.
Yan-Ming YangPharmaceutical Preparation Section, Children's Hospital of Kunming Medical University, Kunming, China.
Yan LiuPharmaceutical Preparation Section, Children's Hospital of Kunming Medical University, Kunming, China.
Hui-Ying LiPharmaceutical Preparation Section, Children's Hospital of Kunming Medical University, Kunming, China.
Kunming Children's Hospital · CNKunming Medical University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) play important roles in human diseases. They control gene expression levels and influence various biological processes through multiple mechanisms. Functional abnormalities in lncRNAs are strongly associated with occurrence and development of various diseases. LINC00472, which is located on chromosome 6q13, is involved in several human diseases, particularly cancers of the breast, lung, liver, osteosarcoma, bladder, colorectal, ovarian, pancreatic and stomach. Importantly, LINC00472 can be used as a biomarker for breast cancer cell sensitivity to chemotherapeutic regimens, including doxorubicin. LINC00472 is regulated by microRNAs and several signaling pathways. However, the significance of LINC00472 in human diseases has not been clearly established. In this review, we elucidate on the significance of LINC00472 in various human diseases, indicating that LINC00472 may be a diagnostic, prognostic as well as therapeutic target for these diseases.

Indexed as

biological functionsbiomarkerclinical applicationLINC00472mechanism

Identifiers

PMID34987381
PMCPMC8722734
OpenAlexW4200022560

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.