Evidence map›Paper›PMID 34988653›Full record

ArticleEuropean journal of nutrition2022

Red blood cell fatty acids and age-related macular degeneration in postmenopausal women.

Andrea Elmore, William S Harris, Lina Mu, William E Brady, Kathleen M Hovey, Julie A Mares, Mark A Espeland, Mary N Haan, Amy E Millen

Abstract read
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In one paragraph

Article in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Andrea ElmoreDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, 270 Farber Hall, Buffalo, NY, 14214-8001, USA.
William S HarrisOmegaQuant Analytics, LLC and Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA.
Lina MuDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, 270 Farber Hall, Buffalo, NY, 14214-8001, USA.
William E BradyDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Kathleen M HoveyDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, 270 Farber Hall, Buffalo, NY, 14214-8001, USA.
Julie A MaresDepartment of Ophthalmology and Visual Sciences, The University of Wisconsin-Madison, Madison, WI, USA.
Mark A EspelandDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Mary N HaanDivision of Clinical Trials and MultiCenter Studies, Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Amy E MillenDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, 270 Farber Hall, Buffalo, NY, 14214-8001, USA. aemillen@buffalo.edu.ORCID http://orcid.org/0000-0001-9011-4869
University at Buffalo, State University of New York · USRoswell Park Comprehensive Cancer Center · USUniversity of California, San Francisco · USUniversity of South Dakota · USUniversity of Wisconsin–Madison · USWake Forest University · US

Funding

NHLBI NIH HHS HHSN268201100001CNHLBI NIH HHS HHSN268201100002CNHLBI NIH HHS HHSN268201100003CNHLBI NIH HHS HHSN268201100004CNHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN271201100004C.NHLBI NIH HHS NIH contract HHSN268200900036C
6 · The paper itself

Abstract

purposeTo evaluate the relationship between red blood cell (RBC) polyunsaturated fatty acid (PUFA) levels, and dietary PUFA and fish intake, with prevalent and incident age-related macular degeneration (AMD) in a US cohort of postmenopausal women.

methodsThis analysis included 1456 postmenopausal women from the Women's Health Initiative (WHI) Clinical Trials. RBC PUFAs were measured from fasting serum samples collected at WHI baseline. Dietary PUFAs and fish intake were assessed via food frequency questionnaires at baseline. There were 240 women who had prevalent AMD and 138 who self-reported AMD development over 9.5 years. Adjusted odds ratios and 95% confidence intervals were estimated for prevalent AMD by RBC PUFA levels, dietary PUFA intake, and frequency of fish consumption. Adjusted hazard ratios and 95% confidence intervals were estimated for incident AMD. A p-for-trend was estimated for continuous measures of dietary PUFA and fish intake.

resultsNo significant association was found between prevalent or incident AMD and RBC docosahexaenoic acid (DHA) + eicosapentaenoic acid (EPA), EPA, DHA, alpha-linolenic acid (ALA), linoleic acid (LA), or arachidonic acid (AA). A positive association was found between dietary intake of AA and odds of prevalent AMD (p-for-trend for continuous AA intake = 0.02) and between intake of LA/ALA and incident AMD (p-for-trend for continuous ratio of LA/ALA intake = 0.03). No statistically significant associations were found between AMD and dietary intake of PUFAs or fish.

conclusionsRBC PUFAs were not associated with AMD in this cohort. Overall, dietary analyses of PUFAs supported this, excepting dietary AA intake and intake of LA in proportion to ALA of which there were trends of increased risk.

Indexed as

Fatty Acids, Omega-3Macular DegenerationAnimalsEicosapentaenoic AcidErythrocytesFatty AcidsFemaleHumansPostmenopauseEicosapentaenoic AcidFatty AcidsFatty Acids, Omega-3Age-related macular degenerationCohortDietEpidemiologyFatty acidsPost-menopausal womenRetinal disease

Identifiers

PMID34988653
OpenAlexW4206789144

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.