Evidence map›Paper›PMID 34989478›Full record

ArticleActa physiologica (Oxford, England)2022

EP

Jean-Claude Kresse, Henricus A M Mutsaers, Michael Schou Jensen, Stine Julie Tingskov, Mia Gebauer Madsen, Lene N Nejsum, Helle Praetorius, Rikke Nørregaard

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta physiologica (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Evaluation of Epithelial Integrity in Human Precision-Cut Kidney Slices.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. EPActa physiologica (Oxford, England) · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jean-Claude KresseDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-5978-2073
Henricus A M MutsaersDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-9553-8860
Michael Schou JensenDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-5230-9657
Stine Julie TingskovDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Mia Gebauer MadsenDepartment of Urology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0003-1407-6914
Lene N NejsumDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0003-4368-8821
Helle PraetoriusDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-0970-5061
Rikke NørregaardDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-0580-373X
Aarhus University · DKAarhus University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimRenal fibrosis is a major driver of chronic kidney disease, yet current treatment strategies are ineffective in attenuating fibrogenesis. The cyclooxygenase/prostaglandin system plays a key role in renal injury and holds great promise as a therapeutic target. Here, we used a translational approach to evaluate the role of the PGE

methodsThe anti-fibrotic efficacy of a selective EP

resultsEP

conclusionThis study highlights the EP

Indexed as

Kidney DiseasesUreteral ObstructionAnimalsCollagenDibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazideDisease Models, AnimalDogsFemaleFibrosisHumansKidneyMaleMiceTransforming Growth Factor betaCollagenDibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazideTransforming Growth Factor betachronic kidney diseasehuman precision-cut kidney slicesprostaglandin E2 EP1 receptorrenal fibrosis

Identifiers

PMID34989478
PMCPMC9286353
OpenAlexW4205287816

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.