Evidence map›Paper›PMID 34990021›Full record

ArticleFEBS letters2022

PIP

Charles T Jakubik, Claire C Weckerly, Gerald R V Hammond, Anne R Bresnick, Jonathan M Backer

Open access · greenAbstract read
In one paragraph

Article in FEBS letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Charles T JakubikDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0002-3151-312X
Claire C WeckerlyDepartment of Cell Biology, University of Pittsburgh School of Medicine, PA, USA.ORCID 0000-0003-2368-8429
Gerald R V HammondDepartment of Cell Biology, University of Pittsburgh School of Medicine, PA, USA.ORCID 0000-0002-6660-3272
Anne R BresnickDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0003-1674-4568
Jonathan M BackerDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0002-0360-5692
Albert Einstein College of Medicine · USUniversity of Pittsburgh · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
The Biology of Lung Metastasis in Breast CancerP01CA257885 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Maja Hrzenjak Oktay · 2022 to 2026
$11.9M
Directing Membrane Function with Inositol Lipids in Health and DiseaseR35GM119412 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gerald R Hammond · 2016 to 2026
$4.3M
Regulation of the Class IA PI 3-kinase PIK3CBR01GM112524 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BACKER, JONATHAN M., BRESNICK, ANNE R · 2014 to 2017
$1.6M
Interinstitutional Program in Cell and Molecular Biology: A Graduate Training Path to Promote Traditional and Non-Traditional Professional OutcomesT32GM133353 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRODSKY, JEFFREY L., MURRAY, SANDRA ANN · 2020 to 2024
$1.5M
NCI NIH HHS P01 CA257885NIGMS NIH HHS R01 GM112524NIGMS NIH HHS R35 GM119412NIGMS NIH HHS T32 GM007288NIGMS NIH HHS T32 GM133353
6 · The paper itself

Abstract

PI3Kβ is required for invadopodia-mediated matrix degradation by breast cancer cells. Invadopodia maturation requires GPCR activation of PI3Kβ and its coupling to SHIP2 to produce PI(3,4)P

Indexed as

Cell Line, TumorCell MovementClass I Phosphatidylinositol 3-KinasesDiglyceridesExtracellular MatrixFemaleGene Expression RegulationHEK293 CellsHumansMammary Glands, HumanMutationPhosphatidylinositol-3,4,5-Trisphosphate 5-PhosphatasesPhosphatidylinositol PhosphatesPodosomesSignal Transduction1,2-dioctanoylglycerolClass I Phosphatidylinositol 3-KinasesDiglyceridesINPPL1 protein, humanPhosphatidylinositol-3,4,5-Trisphosphate 5-PhosphatasesPhosphatidylinositol PhosphatesPIK3CA protein, humanPIK3CB protein, humaninvadopodiamatrix degradationPI 3-kinase

Identifiers

PMID34990021
PMCPMC8885911
OpenAlexW4206033181

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.