ArticleScience (New York, N.Y.)2022
Dense functional and molecular readout of a circuit hub in sensory cortex.
Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 77 citations in OpenAlex.
- Strong connections of locally clustered neurons in the upper-layer cortex underlie schizophrenia-related auditory deviance detection.Science advances · 2026Article
- Learning how to experience the world: From circuits to cell types to genes.Current opinion in neurobiology · 2026Review
- Constructing mesoscale functionomics by neural dynamics subspace clustering.National science review · 2026Article
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- The primate claustrum as a hub for precision weighting of prediction errors across the cortical hierarchy.PLoS biology · 2026Article
- In situ graphene-seq: spatial transcriptomics and chronic electrophysiological characterization of tissue microenvironments.Nature communications · 2026Article
- Association learning drives synaptic plasticity at feedforward synapses in somatosensory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- A transcriptomic axis aligns with in vivo functional dynamics in hippocampal inhibitory circuits.bioRxiv : the preprint server for biology · 2026Article
- A transient sex-biased transcriptional program shapes early postnatal L2/3 neuron development.Biology of sex differences · 2026Article
- Global error signal guides local optimization in mismatch calculation.Nature communications · 2026Article
- Post-Critical Period Transcriptional and Physiological Adaptations of Primary Sensory Cortex after Sensory Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Voltage imaging as a window into neural computation.Neurophotonics · 2026Article
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- Spatially Resolved Profiling of Compartmentalized Muscle and Brain Inflammation.European journal of immunology · 2025Review
- Heterogeneous plasticity of amygdala interneurons in associative learning and extinction.Nature communications · 2025Article
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- Advances in intravital imaging of adult neurogenesis in mice.Stem cell reports · 2025Review
- Three-photon microscopy: an emerging technique for deep intravital brain imaging.Nature reviews. Neuroscience · 2025Review
- Duet model unifies diverse neuroscience experimental findings on predictive coding.bioRxiv : the preprint server for biology · 2025Article
- 2P-NucTag: on-demand phototagging for molecular analysis of functionally identified cortical neurons.bioRxiv : the preprint server for biology · 2025Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Although single-cell transcriptomics of the neocortex has uncovered more than 300 putative cell types, whether this molecular classification predicts distinct functional roles is unclear. We combined two-photon calcium imaging with spatial transcriptomics to functionally and molecularly investigate cortical circuits. We characterized behavior-related responses across major neuronal subclasses in layers 2 or 3 of the primary somatosensory cortex as mice performed a tactile working memory task. We identified an excitatory intratelencephalic cell type, Baz1a, that exhibits high tactile feature selectivity. Baz1a neurons homeostatically maintain stimulus responsiveness during altered experience and show persistent enrichment of subsets of immediately early genes. Functional and anatomical connectivity reveals that Baz1a neurons residing in upper portions of layers 2 or 3 preferentially innervate somatostatin-expressing inhibitory neurons. This motif defines a circuit hub that orchestrates local sensory processing in superficial layers of the neocortex.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.