Evidence map›Paper›PMID 34991601›Full record

ArticleJournal of nanobiotechnology2022

Ultrasensitive dynamic light scattering immunosensing platform for NT-proBNP detection using boronate affinity amplification.

Jiaqi Hu, Lu Ding, Jing Chen, Jinhua Fu, Kang Zhu, Qian Guo, Xiaolin Huang, Yonghua Xiong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jiaqi Hu *State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Nanchang University, Nanchang, 330047, People's Republic of China.
Lu Ding *Hypertension Research Institute of Jiangxi Province, Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
Jing ChenState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Nanchang University, Nanchang, 330047, People's Republic of China.
Jinhua FuJiangxi Agricultural Technology Extension Center, Nanchang, 330046, People's Republic of China.
Kang ZhuState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Nanchang University, Nanchang, 330047, People's Republic of China.
Qian GuoState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Nanchang University, Nanchang, 330047, People's Republic of China.
Xiaolin HuangState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Nanchang University, Nanchang, 330047, People's Republic of China. hxl19880503@163.com.ORCID http://orcid.org/0000-0002-8908-0443
Yonghua XiongState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Nanchang University, Nanchang, 330047, People's Republic of China.
Nanchang University · CNJiangxi Agricultural University · CNNanchang Institute of Technology · CN

Funding

Education Department of Jiangxi Province GJJ200221Jiangxi Provincial Natural Science Foundation 20202ACB215004National Natural Science Foundation of China 32001788National Natural Science Foundation of China 32160599
6 · The paper itself

Abstract

Herein, we reported a new dynamic light scattering (DLS) immunosensing technology for the rapid and sensitive detection of glycoprotein N-terminal pro-brain natriuretic peptide (NT-proBNP). In this design, the boronate affinity recognition based on the interaction of boronic acid ligands and cis-diols was introduced to amplify the nanoparticle aggregation to enable highly sensitive DLS transduction, thereby lowering the limit of detection (LOD) of the methodology. After covalently coupling with antibodies, magnetic nanoparticles (MNPs) were employed as the nanoprobes to selectively capture trace amount of NT-proBNP from complex samples and facilitate DLS signal transduction. Meanwhile, silica nanoparticles modified with phenylboronic acid (SiO

Indexed as

Antibodies, MonoclonalBiosensing TechniquesBoronic AcidsDynamic Light ScatteringHumansImmunoassayLimit of DetectionMagnetite NanoparticlesNatriuretic Peptide, BrainPeptide FragmentsAntibodies, MonoclonalBoronic AcidsMagnetite NanoparticlesNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)AggregationBoronate affinityDynamic light scatteringImmunosensorNT-proBNP

Identifiers

PMID34991601
PMCPMC8740487
OpenAlexW4220879933

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.