Evidence map›Paper›PMID 34992330›Full record

ArticleJournal of materials research2021

Hepatocyte growth factor administration increases bone soluble phosphate and alters bone chemical structure in diabetic hypertensive rats.

Kamal Awad, Natasha G Boyes, Ramlah Iqbal, Mohamed Ahmed, Adel Mohamed, Pranesh Aswath, Corey R Tomczak, Venu Varanasi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 74% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Kamal AwadDepartment of Materials Science and Engineering, College of Engineering, University of Texas at Arlington, Arlington, TX 76019, USA.
Natasha G BoyesCollege of Kinesiology, University of Saskatchewan, Saskatoon, SK, Canada.
Ramlah IqbalCollege of Kinesiology, University of Saskatchewan, Saskatoon, SK, Canada.
Mohamed AhmedDepartments of Anatomy, Physiology, and Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Adel MohamedDepartments of Anatomy, Physiology, and Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Pranesh AswathDepartment of Materials Science and Engineering, College of Engineering, University of Texas at Arlington, Arlington, TX 76019, USA.
Corey R TomczakCollege of Kinesiology, University of Saskatchewan, Saskatoon, SK, Canada.
Venu VaranasiDepartment of Materials Science and Engineering, College of Engineering, University of Texas at Arlington, Arlington, TX 76019, USA.
University of Saskatchewan · CAThe University of Texas at Arlington · US

Funding

An Inverted Nikon A1R Laser Scanning Confocal MicroscopeS10OD025230 · OD · UNIVERSITY OF TEXAS ARLINGTON · PI PAN, ZUI · 2019 to 2019
$449k
Printing and Regenerating Fractured Bone Using Antioxidant MaterialsR56DE027964 · NIDCR · UNIVERSITY OF TEXAS ARLINGTON · PI VARANASI, VENU GOPAL · 2019 to 2019
$428k
Silicon, a Novel Antioxidant Role in Bone HealingR03DE023872 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI VARANASI, VENU GOPAL · 2014 to 2015
$229k
NIDCR NIH HHS R03 DE023872NIDCR NIH HHS R56 DE027964NIH HHS S10 OD025230
6 · The paper itself

Abstract

Hepatocyte growth factor (HGF) is a novel potential therapy for improving bone health in patients with type II diabetes and hypertension, but its effect on the bone molecular structure is not revealed yet. Here, X-ray absorption near edge structure (XANES) spectroscopy was used to explore the effects elicited by HGF on the bone chemical structure. This study assessed local calcium (Ca) and phosphorus (P) coordination of diabetic hypertensive rat bones, each with and without HGF treatment. Results revealed that HGF has significant effects on Ca and P coordination chemistry as confirmed by presence of more soluble phosphates in the HGT-treated groups. Data indicated that treated bones have a poorly developed phosphate structure as evidenced by drastic drop in post-edge shoulder in P L

Identifiers

PMID34992330
PMCPMC8725793
OpenAlexW4206721625

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.