ArticleCirculation1987
Intermittent claudication, exercise, and blood rheology.
Article in Circulation, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03883412 (Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes ( ZQL007)
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 185 citations in OpenAlex.
- Exercise for intermittent claudication.The Cochrane database of systematic reviews · 2017Pooled it
- Effects of a 6-month exercise program pilot study on walking economy, peak physiological characteristics, and walking performance in patients with peripheral arterial disease.Vascular health and risk management · 2012Trial
- Examination of Lower Limb Microcirculation in Diabetic Patients with and without Intermittent Claudication.Biomedicines · 2023Article
- Metabolite patterns associated with individual response to supervised exercise therapy in patients with intermittent claudication.JVS-vascular science · 2022Article
- Patients with Diabetes Complicated by Peripheral Artery Disease: the Current State of Knowledge on Physiotherapy Interventions.Journal of diabetes research · 2021Review
- Community walking programs for treatment of peripheral artery disease.Journal of vascular surgery · 2013Review
- Peripheral arterial occlusive disease: magnetic resonance imaging and the role of aggressive medical management.World journal of surgery · 2007Review
- Optimising exercise training in peripheral arterial disease.Sports medicine (Auckland, N.Z.) · 2004Review
- A prospective evaluation of sensitivity and specificity of the ankle/brachial index in the follow-up of superficial femoral artery occlusions treated by angioplasty.The Clinical investigator · 1994Article
- Physical activity and risk of peripheral arterial disease in the general population: Edinburgh Artery Study.Journal of epidemiology and community health · 1993Article
- Regular exercise reduces fibrinogen levels: a review of longitudinal studies.British journal of sports medicine · 1993Review
- Exercise, fibrinogen, and other risk factors for ischaemic heart disease. Caerphilly Prospective Heart Disease Study.British heart journal · 1993Article
- The clinical importance of erythrocyte deformability, a hemorrheological parameter.Annals of hematology · 1992Review
- Peripheral vascular disease. Benefits of exercise.Sports medicine (Auckland, N.Z.) · 1991Article
- Peripheral vascular disease.BMJ (Clinical research ed.) · 1989Review
- Treating claudication in five words.British medical journal (Clinical research ed.) · 1988Article
- Current strategies in the diagnosis and management of lower extremity peripheral vascular disease.Journal of general internal medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Forty-two stable patients with claudication were assigned to two groups. Group I (n = 22) was submitted to regular, standardized treadmill exercise for 2 months. During this time the maximal and pain-free walking distances increased significantly (more than 100%). Group II (n = 20) patients did not exercise over the same period of time, and their walking distances remained essentially unchanged. No drugs or other forms of treatment were given in either group. The rheology of blood, as quantified by blood and plasma viscosity, hematocrit, blood filterability, and red cell aggregation, was initially abnormal in patients as compared with matched controls. Blood and plasma viscosity, blood cell filterability, and red cell aggregation normalized significantly in group I, but remained pathologic in group II. The hemorrheologic values of patients after 2 months of exercise did no longer differ significantly from those of healthy controls. The "fluidification" of blood induced by regular exercise was qualitatively and quantitatively similar to that obtainable by hemorrheologically active medications. The results confirm that physical training is clinically effective in patients suffering from claudication. They furthermore suggest that training may be looked on as a form of "hemorrheologic therapy" suitable for increasing the fluidity of blood in patients with ischemic diseases. Part of the benefits of regular exercise in stage II occlusive peripheral arterial disease may result from changes in hemorrheology; further studies are needed to define the mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.