Evidence map›Paper›PMID 34997120›Full record

ArticleScientific reports2022

Comparison of cytotoxicity effects induced by four different types of nanoparticles in human corneal and conjunctival epithelial cells.

Xiangzhe Li, Boram Kang, Youngsub Eom, Jingxiang Zhong, Hyung Keun Lee, Hyo Myung Kim, Jong Suk Song

Open access · goldAbstract readComparative Study
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  11. Impact of mucus modulation byInternational journal of pharmaceutics: X · 2023
    Article
  12. Corneal Vascularization Associated With a Novel PDGFRB Variant.Investigative ophthalmology & visual science · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Xiangzhe LiDepartment of Ophthalmology, Guro Hospital, Korea University College of Medicine, 80, Guro-dong, Guro-gu, Seoul, 152-703, South Korea.
Boram KangDepartment of Ophthalmology, Guro Hospital, Korea University College of Medicine, 80, Guro-dong, Guro-gu, Seoul, 152-703, South Korea.
Youngsub EomDepartment of Ophthalmology, Guro Hospital, Korea University College of Medicine, 80, Guro-dong, Guro-gu, Seoul, 152-703, South Korea.
Jingxiang ZhongDepartment of Ophthalmology, First Affiliated Hospital of Jinan University, Guangzhou, China.
Hyung Keun LeeInstitute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, South Korea.
Hyo Myung KimDepartment of Ophthalmology, Guro Hospital, Korea University College of Medicine, 80, Guro-dong, Guro-gu, Seoul, 152-703, South Korea.
Jong Suk SongDepartment of Ophthalmology, Guro Hospital, Korea University College of Medicine, 80, Guro-dong, Guro-gu, Seoul, 152-703, South Korea. crisim@korea.ac.kr.
Korea University Medical Center · KRFirst Affiliated Hospital of Jinan University · CNJinan University · CNYonsei University · KR

Funding

National Research Foundation of Korea (NRF) NRF-2017R1D1A1B03028552
6 · The paper itself

Abstract

The impact of particulate matter (PM) on ocular surface health has attracted increased attention in recent years. Previous studies have reported that differences in the chemical composition of PM can affect the toxicological response. However, available information on the toxic effects of chemical components of PM on the ocular surface is insufficient. In this paper, we aimed to investigate the toxicity effects of chemical components of PM on the ocular surface, focusing on the effects of four different types of nanoparticles (NPs) in human corneal epithelial cells (HCECs) and human conjunctival epithelial cells (HCjECs), which include titanium dioxide (TiO

Indexed as

ApoptosisCells, CulturedConjunctivaEpithelial CellsEpithelium, CornealHumansMetal NanoparticlesMitochondriaNanoparticlesOxidative StressReactive Oxygen SpeciesSilicon DioxideSirtuin 1SootTitaniumZinc OxideReactive Oxygen SpeciesSilicon DioxideSIRT1 protein, humanSirtuin 1SootTitaniumtitanium dioxideZinc Oxide

Identifiers

PMID34997120
PMCPMC8742118
OpenAlexW4205779651

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.