ReviewStroke2022
Imaging Markers of Vascular Brain Health: Quantification, Clinical Implications, and Future Directions.
Review in Stroke, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Association between blood neurofilament light chain levels and vascular cognitive impairment: a systematic review and meta-analysis.Frontiers in neuroscience · 2026Pooled it
- Perivascular Spaces as Determinants of Amyloid, Tau, and Vascular Biomarker Progression.Annals of neurology · 2026Article
- Unravelling the genetic architecture of cerebral small vessel disease in the context of stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Voxelwise correlation of neighbors as a hypothesis driven framework for characterizing white matter lesion heterogeneity.Scientific reports · 2026Article
- Imaging markers of vascular cognitive impairment: Current advances and future directions.Cerebral circulation - cognition and behavior · 2026Article
- Enhancing brain age estimation with structural MRI and synthesized cerebral blood volume maps.Brain communications · 2026Article
- Perivascular diffusion and white matter free water improve identification of cognitive impairment in cerebral small vessel disease.Frontiers in neurology · 2026Article
- MRI signatures associated with active ischemia and disease severity in cerebral small vessel disease.Neuroimage. Reports · 2025Article
- Article
- Plasma NfL and GFAP for predicting VCI and related brain changes in community and clinical cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- WMH Contributions to Cognitive Impairment: Rationale and Design of the Diverse VCID Study.Stroke · 2025Review
- AI-Assisted Compressed Sensing Enables Faster Brain MRI for the Elderly: Image Quality and Diagnostic Equivalence with Conventional Imaging.International journal of general medicine · 2025Article
- Functional Segregation-Integration Preference Configures the Cognitive Decline Against Cerebral Small Vessel Disease: An MRI Study.CNS neuroscience & therapeutics · 2024Article
- Time-encoded ASL reveals lower cerebral blood flow in the early AD continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Heart-brain mapping: Cardiac atrial function is associated with distinct cerebral regions with high free water in older adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Plasma VEGFA and PGF impact longitudinal tau and cognition in preclinical Alzheimer's disease.Brain : a journal of neurology · 2024Article
- Cerebrovascular Abnormalities in Adults Born SGA at 12 Years After Growth Hormone Cessation Compared to Controls.The Journal of clinical endocrinology and metabolism · 2024Article
- Vessel density mapping of small cerebral vessels on 3D high resolution black blood MRI.NeuroImage · 2024Article
- Vascular risk, gait, behavioral, and plasma indicators of VCID.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cerebral artery and brain pathology correlates of antemortem cerebral artery 4D flow MRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
Cerebrovascular disease (CVD) manifests through a broad spectrum of mechanisms that negatively impact brain and cognitive health. Oftentimes, CVD changes (excluding acute stroke) are insufficiently considered in aging and dementia studies which can lead to an incomplete picture of the etiologies contributing to the burden of cognitive impairment. Our goal with this focused review is 3-fold. First, we provide a research update on the current magnetic resonance imaging methods that can measure CVD lesions as well as early CVD-related brain injury specifically related to small vessel disease. Second, we discuss the clinical implications and relevance of these CVD imaging markers for cognitive decline, incident dementia, and disease progression in Alzheimer disease, and Alzheimer-related dementias. Finally, we present our perspective on the outlook and challenges that remain in the field. With the increased research interest in this area, we believe that reliable CVD imaging biomarkers for aging and dementia studies are on the horizon.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.