Evidence map›Paper›PMID 35005193›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021

Long-term trajectories and current BMI are associated with poorer cognitive functioning in middle-aged adults at high Alzheimer's disease risk.

Rebecca K West, Ramit Ravona-Springer, Inbal Sharvit-Ginon, Ithamar Ganmore, Sigalit Manzali, Amir Tirosh, Sapir Golan, Ethel Boccara, Anthony Heymann, Michal Schnaider Beeri

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Rebecca K WestDepartment of Psychiatry Icahn School of Medicine at Mount Sinai New York New York USA.
Ramit Ravona-SpringerThe Joseph Sagol Neuroscience Center Sheba Medical Center Tel-Hashomer Israel.
Inbal Sharvit-GinonThe Joseph Sagol Neuroscience Center Sheba Medical Center Tel-Hashomer Israel.
Ithamar GanmoreThe Joseph Sagol Neuroscience Center Sheba Medical Center Tel-Hashomer Israel.
Sigalit ManzaliThe Joseph Sagol Neuroscience Center Sheba Medical Center Tel-Hashomer Israel.
Amir TiroshSackler School of Medicine Tel Aviv University Tel Aviv Israel.
Sapir GolanThe Joseph Sagol Neuroscience Center Sheba Medical Center Tel-Hashomer Israel.
Ethel BoccaraThe Joseph Sagol Neuroscience Center Sheba Medical Center Tel-Hashomer Israel.
Anthony HeymannMaccabi Healthcare Services Tel Aviv Israel.
Michal Schnaider BeeriDepartment of Psychiatry Icahn School of Medicine at Mount Sinai New York New York USA.
Sheba Medical Center · ILTel Aviv University · ILIcahn School of Medicine at Mount Sinai · US

Funding

Research Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Fanny M Elahi · 2020 to 2026
$31.0M
QUANTITATIVE ANALYSIS OF MICROVASCULAR CHANGES IN THE AGING BRAINP01AG002219 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI HAROUTUNIAN, VAHRAM · 1985 to 2009
$19.2M
Systemic and dietary advanced glycation end products in type 2 diabetes-related cognitive decline and incident dementia: effects on Alzheimer's pathology and cerebrovascular diseaseR01AG061093 · NIA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI SCHNAIDER BEERI, MICHAL · 2019 to 2024
$4.3M
Peripheral and brain levels of advanced glycation end products AGEs and incident Alzheimers disease and neuropathologyR01AG053446 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHNAIDER BEERI, MICHAL, URIBARRI, JAIME · 2016 to 2021
$3.8M
Inflammation, long-term diabetes characteristics, and cognitive declineR01AG034087 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHNAIDER BEERI, MICHAL · 2009 to 2014
$3.7M
Hyperbaric oxygen therapy for cognition in diabetic elderly at high dementia riskR01AG051545 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SANO, MARY, SCHNAIDER BEERI, MICHAL · 2016 to 2021
$3.7M
NIA NIH HHS P01 AG002219NIA NIH HHS P30 AG066514NIA NIH HHS R01 AG034087NIA NIH HHS R01 AG051545NIA NIH HHS R01 AG053446NIA NIH HHS R01 AG061093
6 · The paper itself

Abstract

introductionWe examined relationships of body mass index (BMI) with cognition in middle-aged adults at Alzheimer's disease (AD) risk due to parental family history.

methodsParticipants are offspring of AD patients from the Israel Registry of Alzheimer's Prevention (N = 271). Linear regressions assessed associations of BMI and cognition, and whether associations differed by maternal/paternal history. Analyses of covariance examined associations of long-term trajectories of BMI with cognition.

resultsHigher BMI was associated with worse language ( DISCUSSION: Higher BMI and overweight/obese trajectories were associated with poorer cognition in adults with maternal history of AD, but not those with paternal history.

Indexed as

adiposityAlzheimer's diseasecognitioncognitive declineobesityparental history of Alzheimer's diseaserisk factors

Identifiers

PMID35005193
PMCPMC8719431
OpenAlexW4205597701

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.