Evidence map›Paper›PMID 35005206›Full record

ArticleAlzheimer's & dementia (New York, N. Y.)2021

The Worldwide Alzheimer's Disease Neuroimaging Initiative: ADNI-3 updates and global perspectives.

Christopher J Weber, Maria C Carrillo, William Jagust, Clifford R Jack, Leslie M Shaw, John Q Trojanowski, Andrew J Saykin, Laurel A Beckett, Cyrille Sur, Naren P Rao and 12 more

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's & dementia (New York, N. Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Association of cognitive impairment and APOE ε4 with Centiloids in Hispanic and non-Hispanic White cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Pooled it
  2. Article
  3. Article
  4. Encoding Discordance in the Alzheimer's Disease A/T/N Framework.medRxiv : the preprint server for health sciences · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Cognitive dispersion profiles and prediction of cognitive change in early-onset dementias: Results from LEADS.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Advancing global dementia research through equity and inclusion.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 19 institutions in 11 countries.

Christopher J WeberAlzheimer's Association Chicago Illinois USA.
Maria C CarrilloAlzheimer's Association Chicago Illinois USA.
William JagustSchool of Public Health and Helen Wills Neuroscience Institute University of California Berkeley Berkeley California USA.
Clifford R JackDepartment of Radiology Mayo Clinic Rochester Minnesota USA.
Leslie M ShawDepartment of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA.
John Q TrojanowskiDepartment of Pathology and Laboratory Medicine Perelman School of Medicine Institute on Aging Perelman School of Medicine Alzheimer's Disease Core Center, Perelman School of Medicine Udall Parkinson's Research Center Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA.
Andrew J SaykinDepartment of Radiology and Imaging Sciences and the Indiana Alzheimer's Disease Research Center Department of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis Indiana USA.
Laurel A BeckettDivision of Biostatistics Department of Public Health Sciences University of California Davis California USA.
Cyrille SurMerck Research Laboratories Merck Kenilworth New Jersey USA.
Naren P RaoDepartment of Psychiatry National Institute of Mental Health and Neurosciences Bengaluru Karnataka India.
Patricio Chrem MendezCentro de Memoria FLENI Montañeses, 2325 (C1428AQK), Bs As Buenos Aires Argentina.
Sandra E BlackDepartment of Medicine (Neurology) Hurvitz Brain Sciences Program Canadian Partnership for Stroke Recovery, and LC Campbell Cognitive Neurology Research Unit Hurvitz Brain Sciences Research Program Sunnybrook Research Institute Sunnybrook Health Sciences Centre University of Toronto Toronto Canada.
Kuncheng LiDepartment of Radiology Xuanwu Hospital of Capital Medical University Beijing China.
Takeshi IwatsuboDepartment of Neuropathology Graduate School of Medicine The University of Tokyo Tokyo Japan.
Chiung-Chih ChangDepartment of General Neurology and Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung Taiwan.
Ana Luisa SosaNational Institute of Neurology and Neurosurgery of Mexico Mexico City Mexico.
Christopher C RoweDepartment of Molecular Imaging and Therapy Austin Health and Florey Department of Neuroscience and Mental Health University of Melbourne Melbourne Victoria Australia.
Richard J PerrinCharles F. and Joanne Knight Alzheimer Disease Research Center Department of Pathology and Immunology Department of Neurology Washington University School of Medicine Saint Louis Missouri USA.
John C MorrisCharles F. and Joanne Knight Alzheimer Disease Research Center Department of Neurology Washington University School of Medicine Saint Louis Missouri USA.
Amanda M B HealanIndependent Science Writer and Editor Nashville Tennessee USA.
Stephen E HallAlzheimer's Association Chicago Illinois USA.
Michael W WeinerDepartment of Veterans Affairs Medical Center Center for Imaging of Neurodegenerative Diseases Department of Radiology Department of Medicine Department of Psychiatry Department of Neurology University of California San Francisco California USA.
Alzheimer's Association · USHope Center for Neurological Disorders · USCapital Medical University · CNChang Gung University · TWFundación para la Lucha contra las Enfermedades Neurológicas de la Infancia · ARHealth Sciences Centre · CAIndiana University School of MedicineInstitute on Aging · USInstituto Nacional de Neurología y Neurocirugía · MXMayo Clinic · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USNational Institute of Mental Health and Neurosciences · INOldham Council · GBSan Francisco VA Medical Center · USThe University of Tokyo · JPUniversity of California, Berkeley · USUniversity of California, Davis · USUniversity of Melbourne · AUUniversity of Pennsylvania · US

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MONICA G. RIVERA-MINDT · 2016 to 2026
$226.7M
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
NIA NIH HHS U19 AG024904NIA NIH HHS U24 AG021886
6 · The paper itself

Abstract

The Worldwide Alzheimer's Disease Neuroimaging Initiative (WW-ADNI) is a collaborative effort to investigate imaging and biofluid markers that can inform Alzheimer's disease treatment trials. It is a public-private partnership that spans North America, Argentina, Australia, Canada, China, Japan, Korea, Mexico, and Taiwan. In 2004, ADNI researchers began a naturalistic, longitudinal study that continues today around the globe. Through several successive phases (ADNI-1, ADNI-GO, ADNI-2, and ADNI-3), the study has fueled amyloid and tau phenotyping and refined neuroimaging methodologies. WW-ADNI researchers have successfully standardized analyses and openly share data without embargo, providing a rich data set for other investigators. On August 26, 2020, the Alzheimer's Association convened WW-ADNI researchers who shared updates from ADNI-3 and their vision for ADNI-4.

Indexed as

Alzheimer's diseaseamyloidbiomarkerscerebrospinal fluidcognitive impairmentMRIneuroimagingPETTau

Identifiers

PMID35005206
PMCPMC8719344
OpenAlexW4206382244

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.