Evidence map›Paper›PMID 35006284›Full record

ReviewArchives of toxicology2022

3D bioprinting of complex tissues in vitro: state-of-the-art and future perspectives.

Yi Xiang, Kathleen Miller, Jiaao Guan, Wisarut Kiratitanaporn, Min Tang, Shaochen Chen

Abstract readReview
In one paragraph

Review in Archives of toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Understanding Glioblastoma Dynamics Using 3D Organoids and Engineered Extracellular Matrix.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Review
  4. Article
  5. 3D Printing for Neural Repair: Bridging the Gap in Regenerative Medicine.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
  6. Article
  7. Advances in human induced pluripotent stem cell (hiPSC)-based disease modelling in cardiogenetics.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2025
    Article
  8. Review
  9. Materials today. Bio · 2025
    Article
  10. Extrusion bioprinting: meeting the promise of human tissue biofabrication?Progress in biomedical engineering (Bristol, England) · 2025
    Review
  11. Heterogeneous and Composite Bioinks for 3D-Bioprinting of Complex Tissue.Biomedical materials & devices (New York, N.Y.) · 2025
    Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi XiangDepartment of NanoEngineering, University of California San Diego, La Jolla, USA.
Kathleen MillerDepartment of NanoEngineering, University of California San Diego, La Jolla, USA.
Jiaao GuanDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, USA.
Wisarut KiratitanapornDepartment of NanoEngineering, University of California San Diego, La Jolla, USA.
Min TangDepartment of NanoEngineering, University of California San Diego, La Jolla, USA.
Shaochen ChenDepartment of NanoEngineering, University of California San Diego, La Jolla, USA. chen168@eng.ucsd.edu.ORCID 0000-0001-6876-497X

Funding

Bioprinting Plant Virus Nanoparticles for Immunotherapy and Relapse Prevention of Ovarian CancerR01CA253615 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN, FIERING, STEVEN · 2020 to 2024
$3.1M
Rapid 3D-printing of Multi-functional Adaptive Nerve ConduitsR33HD090662 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN · 2019 to 2021
$1.1M
Stem Cell-based Human Placenta-on-a-Chip Using 3D BioprintingR21HD100132 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN, LAURENT, LOUISE CHANG · 2019 to 2020
$656k
3D Printing of Precision Scaffolds for Volumetric Muscle Tissue RegenerationR21AR074763 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN · 2019 to 2020
$355k
NCI NIH HHS R01 CA253615NIAMS NIH HHS R21 AR074763NICHD NIH HHS R21 HD100132NICHD NIH HHS R33 HD090662NIH HHS R01CA253615NIH HHS R21AR074763NIH HHS R21HD100132NIH HHS R33HD090662
6 · The paper itself

Abstract

The pharmacology and toxicology of a broad variety of therapies and chemicals have significantly improved with the aid of the increasing in vitro models of complex human tissues. Offering versatile and precise control over the cell population, extracellular matrix (ECM) deposition, dynamic microenvironment, and sophisticated microarchitecture, which is desired for the in vitro modeling of complex tissues, 3D bio-printing is a rapidly growing technology to be employed in the field. In this review, we will discuss the recent advancement of printing techniques and bio-ink sources, which have been spurred on by the increasing demand for modeling tactics and have facilitated the development of the refined tissue models as well as the modeling strategies, followed by a state-of-the-art update on the specialized work on cancer, heart, muscle and liver. In the end, the toxicological modeling strategies, substantial challenges, and future perspectives for 3D printed tissue models were explored.

Indexed as

Models, BiologicalPrinting, Three-DimensionalAnimalsBioprintingExtracellular MatrixHumansPharmacologyTissue EngineeringToxicology3D printingBiomaterialsIn vitro modelTissue engineeringTissue modelToxicity screening

Identifiers

PMID35006284
PMCPMC8850226

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.