Evidence map›Paper›PMID 35008510›Full record

ArticleInternational journal of molecular sciences2021

The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes.

Karolina Seborova, Alzbeta Kloudova-Spalenkova, Kamila Koucka, Petr Holy, Marie Ehrlichova, Changwei Wang, Iwao Ojima, Iveta Voleska, Petr Daniel, Kamila Balusikova and 7 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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  8. Genes · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Karolina SeborovaToxicogenomics Unit, National Institute of Public Health, 100 00 Prague, Czech Republic.ORCID 0000-0002-8925-2321
Alzbeta Kloudova-SpalenkovaToxicogenomics Unit, National Institute of Public Health, 100 00 Prague, Czech Republic.
Kamila KouckaToxicogenomics Unit, National Institute of Public Health, 100 00 Prague, Czech Republic.
Petr HolyToxicogenomics Unit, National Institute of Public Health, 100 00 Prague, Czech Republic.ORCID 0000-0002-6950-5563
Marie EhrlichovaToxicogenomics Unit, National Institute of Public Health, 100 00 Prague, Czech Republic.
Changwei WangInstitute of Chemical Biology & Drug Discovery, Stony Brook University-State University of New York, Stony Brook, NY 11794, USA.
Iwao OjimaInstitute of Chemical Biology & Drug Discovery, Stony Brook University-State University of New York, Stony Brook, NY 11794, USA.
Iveta VoleskaToxicogenomics Unit, National Institute of Public Health, 100 00 Prague, Czech Republic.
Petr DanielDivision of Cell and Molecular Biology, Third Faculty of Medicine, Charles University, 100 00 Prague, Czech Republic.ORCID 0000-0002-5523-4184
Kamila BalusikovaDivision of Cell and Molecular Biology, Third Faculty of Medicine, Charles University, 100 00 Prague, Czech Republic.ORCID 0000-0002-0471-5877
Michael JelinekDivision of Cell and Molecular Biology, Third Faculty of Medicine, Charles University, 100 00 Prague, Czech Republic.
Jan KovarDivision of Cell and Molecular Biology, Third Faculty of Medicine, Charles University, 100 00 Prague, Czech Republic.ORCID 0000-0001-9432-8960
Lukas RobDepartment of Gynecology and Obstetrics, Third Faculty of Medicine and University Hospital Kralovske Vinohrady, 100 00 Prague, Czech Republic.
Martin HrudaDepartment of Gynecology and Obstetrics, Third Faculty of Medicine and University Hospital Kralovske Vinohrady, 100 00 Prague, Czech Republic.
Marcela MrhalovaDepartment of Pathology and Molecular Medicine, Second Faculty of Medicine and Motol University Hospital, 150 06 Prague, Czech Republic.
Pavel SoucekToxicogenomics Unit, National Institute of Public Health, 100 00 Prague, Czech Republic.ORCID 0000-0002-4294-6799
Radka VaclavikovaToxicogenomics Unit, National Institute of Public Health, 100 00 Prague, Czech Republic.
Charles University · CZState University of New York · USUniversity Hospital Kralovske Vinohrady · CZNational Institute of Public Health · CZUniversity Hospital in Motol · CZ

Funding

Tumor -Targeting Chemotherapeutic AgentsR01CA103314 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI OJIMA, IWAO · 2003 to 2013
$3.1M
Charles University PROGRES Q28Czech Health Research Council NU20-09-00174Czech Ministry of Education, Youth and Sports INTER-COST, LTC19020Czech Science Foundation 19-03063SNIH HHS R01 CA103314
6 · The paper itself

Abstract

The main problem precluding successful therapy with conventional taxanes is de novo or acquired resistance to taxanes. Therefore, novel experimental taxane derivatives (Stony Brook taxanes; SB-Ts) are synthesized and tested as potential drugs against resistant solid tumors. Recently, we reported alterations in

Indexed as

Adaptor Proteins, Signal TransducingAnimalsATP-Binding Cassette, Sub-Family C ProteinsBiomarkers, TumorCarbamoyl-Phosphate Synthase (Ammonia)Carcinoma, Ovarian EpithelialCell Line, TumorCell SurvivalDown-RegulationDrug Resistance, NeoplasmFemaleHumansLIM Domain ProteinsMiceMice, NudeMiddle AgedAdaptor Proteins, Signal TransducingATP-Binding Cassette, Sub-Family C ProteinsBiomarkers, TumorCarbamoyl-Phosphate Synthase (Ammonia)CPS1 protein, humanLIM Domain Proteinsmultidrug resistance-associated protein 3PaclitaxelTaxoidsTranscription FactorsTRIP6 protein, humanABCC3CPS1multidrug resistanceovarian carcinomaStony Brook taxanestaxanesTRIP6

Identifiers

PMID35008510
PMCPMC8744980
OpenAlexW4200262453

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.