Evidence map›Paper›PMID 35008595›Full record

ArticleInternational journal of molecular sciences2021

Effect of Denervation on XBP1 in Skeletal Muscle and the Neuromuscular Junction.

Lisa A Walter, Lauren P Blake, Yann S Gallot, Charles J Arends, Randall S Sozio, Stephen M Onifer, Kyle R Bohnert

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. [Advances in the role of miR-378a in skeletal muscle development and diseases].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Lisa A WalterDepartment of Kinesiology, St. Ambrose University, Davenport, IA 52803, USA.
Lauren P BlakeDepartment of Kinesiology, St. Ambrose University, Davenport, IA 52803, USA.
Yann S GallotLBEPS, Univ Evry, IRBA, Université Paris Saclay, 91025 Evry, France.ORCID 0000-0003-4447-1448
Charles J ArendsPalmer Center for Chiropractic Research, Palmer College of Chiropractic, Davenport, IA 52803, USA.
Randall S SozioPalmer Center for Chiropractic Research, Palmer College of Chiropractic, Davenport, IA 52803, USA.ORCID 0000-0002-9935-4292
Stephen M OniferPalmer Center for Chiropractic Research, Palmer College of Chiropractic, Davenport, IA 52803, USA.
Kyle R BohnertDepartment of Kinesiology, St. Ambrose University, Davenport, IA 52803, USA.
Palmer College of Chiropractic · USSaint Ambrose University · USUniversité Paris-Saclay · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Denervation of skeletal muscle is a debilitating consequence of injury of the peripheral nervous system, causing skeletal muscle to experience robust atrophy. However, the molecular mechanisms controlling the wasting of skeletal muscle due to denervation are not well understood. Here, we demonstrate that transection of the sciatic nerve in Sprague-Dawley rats induced robust skeletal muscle atrophy, with little effect on the neuromuscular junction (NMJ). Moreover, the following study indicates that all three arms of the unfolded protein response (UPR) are activated in denervated skeletal muscle. Specifically, ATF4 and ATF6 are elevated in the cytoplasm of skeletal muscle, while XBP1 is elevated in the nuclei of skeletal muscle. Moreover, XBP1 is expressed in the nuclei surrounding the NMJ. Altogether, these results endorse a potential role of the UPR and, specifically, XBP1 in the maintenance of both skeletal muscle and the NMJ following sciatic nerve transection. Further investigations into a potential therapeutic role concerning these mechanisms are needed.

Indexed as

Muscle DenervationSciatic NerveUnfolded Protein ResponseActivating Transcription Factor 4Activating Transcription Factor 6AnimalsGene Expression RegulationMaleMuscle, SkeletalNeuromuscular JunctionRatsRats, Sprague-DawleyX-Box Binding Protein 1Activating Transcription Factor 4Activating Transcription Factor 6Atf4 protein, ratAtf6 protein, ratX-Box Binding Protein 1Xbp1 protein, ratdenervationER Stressneuromuscular junctionskeletal muscle atrophyUPR

Identifiers

PMID35008595
PMCPMC8745577
OpenAlexW4200501833

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.