Evidence map›Paper›PMID 35008656›Full record

ArticleInternational journal of molecular sciences2021

Manganese Is a Strong Specific Activator of the RNA Synthetic Activity of Human Polη.

Eva Balint, Ildiko Unk

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Unscheduled mInternational journal of molecular sciences · 2025
    Article
  2. Review
  3. DNA storage-from natural biology to synthetic biology.Computational and structural biotechnology journal · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Eva BalintBiological Research Centre, Institute of Genetics, Eotvos Loránd Research Network, H-6726 Szeged, Hungary.ORCID 0000-0002-1258-6892
Ildiko UnkBiological Research Centre, Institute of Genetics, Eotvos Loránd Research Network, H-6726 Szeged, Hungary.ORCID 0000-0001-8638-0339
HUN-REN Szegedi Biológiai Kutatóközpont · HU

Funding

National Research, Development and Innovation Office Hungary GINOP-2.3.2-15-2016-00024
6 · The paper itself

Abstract

DNA polymerase η (Polη) is a translesion synthesis polymerase that can bypass different DNA lesions with varying efficiency and fidelity. Its most well-known function is the error-free bypass of ultraviolet light-induced cyclobutane pyrimidine dimers. The lack of this unique ability in humans leads to the development of a cancer-predisposing disease, the variant form of

Indexed as

DNA DamageDNA RepairAdenosine TriphosphateCytidine TriphosphateDNADNA-Directed DNA PolymeraseGuanosine TriphosphateHumansKineticsManganesePyrimidine DimersUridine TriphosphateY-Family DNA PolymerasesAdenosine TriphosphateCytidine TriphosphateDNADNA-Directed DNA PolymeraseGuanosine TriphosphateManganesePyrimidine DimersRad30 proteinUridine TriphosphateY-Family DNA Polymerasesenzyme kineticshuman polymerase ηmanganeseRNA extensiontranslesion synthesis

Identifiers

PMID35008656
PMCPMC8745064
OpenAlexW4200533304

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.