Evidence map›Paper›PMID 35008673›Full record

ArticleInternational journal of molecular sciences2021

Biological Implications of a Stroke Therapy Based in Neuroglobin Hyaluronate Nanoparticles. Neuroprotective Role and Molecular Bases.

María Ángeles Peinado, David Ovelleiro, María Luisa Del Moral, Raquel Hernández, Esther Martínez-Lara, Eva Siles, José Rafael Pedrajas, María Luisa García-Martín, Carlos Caro, Sebastián Peralta and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Neuroprotection by Drugs, Nutraceuticals and Physical Activity.International journal of molecular sciences · 2023
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

María Ángeles PeinadoDepartment of Experimental Biology, Campus de Las Lagunillas s/n, University of Jaén, Building B3, 23071 Jaen, Spain.ORCID 0000-0003-3136-0706
David OvelleiroDepartment of Experimental Biology, Campus de Las Lagunillas s/n, University of Jaén, Building B3, 23071 Jaen, Spain.ORCID 0000-0002-9415-2229
María Luisa Del MoralDepartment of Experimental Biology, Campus de Las Lagunillas s/n, University of Jaén, Building B3, 23071 Jaen, Spain.
Raquel HernándezDepartment of Experimental Biology, Campus de Las Lagunillas s/n, University of Jaén, Building B3, 23071 Jaen, Spain.
Esther Martínez-LaraDepartment of Experimental Biology, Campus de Las Lagunillas s/n, University of Jaén, Building B3, 23071 Jaen, Spain.
Eva SilesDepartment of Experimental Biology, Campus de Las Lagunillas s/n, University of Jaén, Building B3, 23071 Jaen, Spain.ORCID 0000-0003-4192-7008
José Rafael PedrajasDepartment of Experimental Biology, Campus de Las Lagunillas s/n, University of Jaén, Building B3, 23071 Jaen, Spain.ORCID 0000-0003-1998-0638
María Luisa García-MartínBIONAND-Centro Andaluz de Nanomedicina y Biotecnología, Junta de Andalucía, Universidad de Málaga, Parque Tecnológico de Andalucía, 29590 Malaga, Spain.ORCID 0000-0002-2257-7682
Carlos CaroBIONAND-Centro Andaluz de Nanomedicina y Biotecnología, Junta de Andalucía, Universidad de Málaga, Parque Tecnológico de Andalucía, 29590 Malaga, Spain.ORCID 0000-0003-4758-3816
Sebastián PeraltaDepartment of Pharmacy and Pharmaceutical Technology, Campus de Cartuja s/n, School of Pharmacy, University of Granada, 18071 Granada, Spain.
María Encarnación MoralesDepartment of Pharmacy and Pharmaceutical Technology, Campus de Cartuja s/n, School of Pharmacy, University of Granada, 18071 Granada, Spain.
María Adolfina RuizDepartment of Pharmacy and Pharmaceutical Technology, Campus de Cartuja s/n, School of Pharmacy, University of Granada, 18071 Granada, Spain.
Santos BlancoDepartment of Experimental Biology, Campus de Las Lagunillas s/n, University of Jaén, Building B3, 23071 Jaen, Spain.ORCID 0000-0002-4686-5320
Universidad de Jaén · ESUniversidad de Granada · ESAndalusian Centre for Nanomedicine and Biotechnology · ES

Funding

Ministerio de Economía y Competitividad BFU-2016-80316-R
6 · The paper itself

Abstract

Exogenous neuroprotective protein neuroglobin (Ngb) cannot cross the blood-brain barrier. To overcome this difficulty, we synthesized hyaluronate nanoparticles (NPs), able to deliver Ngb into the brain in an animal model of stroke (MCAO). These NPs effectively reached neurons, and were microscopically identified after 24 h of reperfusion. Compared to MCAO non-treated animals, those treated with Ngb-NPs showed survival rates up to 50% higher, and better neurological scores. Tissue damage improved with the treatment, but no changes in the infarct volume or in the oxidative/nitrosative values were detected. A proteomics approach (

Indexed as

AnimalsBlood-Brain BarrierBrain InfarctionEndocytosisGene OntologyInfarction, Middle Cerebral ArteryMagnetic Resonance ImagingMaleNanoparticlesNeuroglobinNeuronsNeuroprotective AgentsNitrosative StressOxidative StressPrincipal Component AnalysisProteomicsNeuroglobinNeuroprotective AgentsThiobarbituric Acid Reactive Substanceshyaluronate nanoparticlesMCAOneuroglobinneuroprotectionproteomicsstroke

Identifiers

PMID35008673
PMCPMC8745106
OpenAlexW4200338226

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.