Evidence map›Paper›PMID 35008802›Full record

ArticleInternational journal of molecular sciences2021

Iron-Chelation Treatment by Novel Thiosemicarbazone Targets Major Signaling Pathways in Neuroblastoma.

Peter Macsek, Jan Skoda, Maria Krchniakova, Jakub Neradil, Renata Veselska

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Transmetalation in Cancer Pharmacology.International journal of molecular sciences · 2025
    Review
  2. Article
  3. Chelators as Antineuroblastomas Agents.Physiological research · 2023
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Peter MacsekLaboratory of Tumor Biology, Department of Experimental Biology, Faculty of Science, Masaryk University, 601 77 Brno, Czech Republic.
Jan SkodaLaboratory of Tumor Biology, Department of Experimental Biology, Faculty of Science, Masaryk University, 601 77 Brno, Czech Republic.ORCID 0000-0002-9292-8177
Maria KrchniakovaLaboratory of Tumor Biology, Department of Experimental Biology, Faculty of Science, Masaryk University, 601 77 Brno, Czech Republic.ORCID 0000-0002-1143-9241
Jakub NeradilLaboratory of Tumor Biology, Department of Experimental Biology, Faculty of Science, Masaryk University, 601 77 Brno, Czech Republic.ORCID 0000-0001-6781-7099
Renata VeselskaLaboratory of Tumor Biology, Department of Experimental Biology, Faculty of Science, Masaryk University, 601 77 Brno, Czech Republic.ORCID 0000-0002-0048-9913
Masaryk University · CZ

Funding

European Regional Development Fund CZ.02.1.01/0.0/0.0/16_019/0000868Ministry of Healthcare of the Czech Republic 16-34083AMinistry of Healthcare of the Czech Republic 17-33104A
6 · The paper itself

Abstract

Despite constant advances in the field of pediatric oncology, the survival rate of high-risk neuroblastoma patients remains poor. The molecular and genetic features of neuroblastoma, such as

Indexed as

Signal TransductionCell Cycle ProteinsCell Line, TumorCell ShapeDown-RegulationErbB ReceptorsGene AmplificationGene SilencingHumansIntracellular Signaling Peptides and ProteinsIron Chelating AgentsModels, BiologicalNeuroblastomaN-myc Downstream-Regulated Gene 1 ProteinN-Myc Proto-Oncogene ProteinPhosphorylationCell Cycle Proteinsdi-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazoneErbB ReceptorsIntracellular Signaling Peptides and ProteinsIron Chelating AgentsN-myc Downstream-Regulated Gene 1 ProteinN-Myc Proto-Oncogene ProteinProto-Oncogene Proteins c-aktPyridinesThiosemicarbazonesDpCEGFRlipid dropletMYCNDRG1neuroblastomathiosemicarbazone

Identifiers

PMID35008802
PMCPMC8745636
OpenAlexW4200102395

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.