Evidence mapPaperPMID 35010701Full record

ArticleInternational journal of environmental research and public health2021

The Interaction of Vitamin D and Corticosteroids: A Mortality Analysis of 26,508 Veterans Who Tested Positive for SARS-CoV-2.

Jimmy T Efird, Ethan J Anderson, Charulata Jindal, Thomas S Redding, Andrew D Thompson, Ashlyn M Press, Julie Upchurch, Christina D Williams, Yuk Ming Choi, Ayako Suzuki

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Observational
  5. Review
  6. Article
  7. Vitamin D status and clinical implications in the adult population of Malaysia: a position paper by the Malaysian Vitamin D Special Interest Group.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Review
  8. Relationship between Vitamin D and Immunity in Older People with COVID-19.International journal of environmental research and public health · 2023
    Review
  9. Vitamin D and COVID-19-Revisited.Journal of internal medicine · 2022
    Review
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Jimmy T EfirdCooperative Studies Program Epidemiology Center, Durham VA Health Care System, Durham, NC 27705, USA.
Ethan J AndersonCollege of Pharmacy, University of Iowa, Iowa City, IA 52242, USA.
Charulata JindalHarvard Medical School, Harvard University, Boston, MA 02115, USA.
Thomas S ReddingCooperative Studies Program Epidemiology Center, Durham VA Health Care System, Durham, NC 27705, USA.
Andrew D ThompsonCooperative Studies Program Epidemiology Center, Durham VA Health Care System, Durham, NC 27705, USA.
Ashlyn M PressCooperative Studies Program Epidemiology Center, Durham VA Health Care System, Durham, NC 27705, USA.ORCID 0000-0001-7359-0505
Julie UpchurchCooperative Studies Program Epidemiology Center, Durham VA Health Care System, Durham, NC 27705, USA.ORCID 0000-0002-2668-2535
Christina D WilliamsCooperative Studies Program Epidemiology Center, Durham VA Health Care System, Durham, NC 27705, USA.
Yuk Ming ChoiSignify Health, Dallas, TX 75244, USA.
Ayako SuzukiCooperative Studies Program Epidemiology Center, Durham VA Health Care System, Durham, NC 27705, USA.
Durham VA Health Care System · USDuke University · USHarvard University · USUniversity of Iowa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This data-based cohort consisted of 26,508 (7%) United States veterans out of the 399,290 who tested positive for SARS-CoV-2 from 1 March to 10 September 2020. We aimed to assess the interaction of post-index vitamin D (Vit D) and corticosteroid (CRT) use on 30-day mortality among hospitalized and non-hospitalized patients with coronavirus disease 2019 (COVID-19). Combination Vit D and CRT drug use was assessed according to four multinomial pairs (-|+, -|-, +|+, +|-). Respective categorical effects were computed on a log-binomial scale as adjusted relative risk (aRR). Approximately 6% of veterans who tested positive for SARS-CoV-2 died within 30 days of their index date. Among hospitalized patients, a significantly decreased aRR was observed for the use of Vit D in the absence of CRTs relative to patients who received CRTs but not Vit D (aRR = 0.30; multiplicity corrected,

Indexed as

COVID-19VeteransAdrenal Cortex HormonesHumansSARS-CoV-2United StatesVitamin DAdrenal Cortex HormonesVitamin Danti-inflammatorycorticosteroidsCOVID-19cytokine stormSARS-CoV-2veteransvitamin D

Identifiers

PMID35010701
PMCPMC8744830
OpenAlexW4205291760

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.