Evidence map›Paper›PMID 35010984›Full record

Trial reportNutrients2021

Artichoke and Bergamot Phytosome Alliance: A Randomized Double Blind Clinical Trial in Mild Hypercholesterolemia.

Antonella Riva, Giovanna Petrangolini, Pietro Allegrini, Simone Perna, Attilio Giacosa, Gabriella Peroni, Milena Anna Faliva, Maurizio Naso, Mariangela Rondanelli

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Effect of Citrus bergamia Supplementation on Body Composition in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Pooled it
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Antonella RivaDevelopment Department, Indena SpA, 20139 Milan, Italy.ORCID 0000-0003-2819-943X
Giovanna PetrangoliniDevelopment Department, Indena SpA, 20139 Milan, Italy.ORCID 0000-0001-6681-7329
Pietro AllegriniDevelopment Department, Indena SpA, 20139 Milan, Italy.ORCID 0000-0002-4380-9577
Simone PernaDepartment of Biology, College of Science, Sakhir Campus, University of Bahrain, Zallaq 32038, Bahrain.ORCID 0000-0002-2720-1473
Attilio GiacosaCDI-Centro Diagnostico Italiano, 20147 Milan, Italy.
Gabriella PeroniEndocrinology and Nutrition Unit, Azienda di Servizi alla Persona ''Istituto Santa Margherita'', University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-1632-1787
Milena Anna FalivaEndocrinology and Nutrition Unit, Azienda di Servizi alla Persona ''Istituto Santa Margherita'', University of Pavia, 27100 Pavia, Italy.
Maurizio NasoEndocrinology and Nutrition Unit, Azienda di Servizi alla Persona ''Istituto Santa Margherita'', University of Pavia, 27100 Pavia, Italy.ORCID 0000-0003-1180-2925
Mariangela RondanelliIRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0001-8336-4851
University of Pavia · ITIndena (Italy) · ITCentro Diagnostico Italiano · ITUniversity of Bahrain · BH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Botanicals are natural alternatives to pharmacological therapies that aim at reducing hypercholesterolemia. In this context, despite bergamot being effective in modulating lipid profile, some subjects failed to achieve a satisfactory response to supplementation. The aim of this study was to evaluate whether the association of 600 mg of bergamot phytosome

Indexed as

CitrusCynara scolymusPhytotherapyAdultAgedDouble-Blind MethodFemaleHumansHypercholesterolemiaMaleMiddle AgedOverweightPlant ExtractsPlant Extractsartichokebergamotbody compositionmild hypercholesterolemiaphytosome®poor responders

Identifiers

PMID35010984
PMCPMC8746931
OpenAlexW4205638225

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.