Evidence map›Paper›PMID 35011087›Full record

ReviewNutrients2022

Interactions between Food and Drugs, and Nutritional Status in Renal Patients: A Narrative Review.

Claudia D'Alessandro, Alessia Benedetti, Antonello Di Paolo, Domenico Giannese, Adamasco Cupisti

Abstract readReview
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. The paradoxical protective effect of malnutrition in acetaminophen-induced liver injury.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Claudia D'AlessandroDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma 56, 56126 Pisa, Italy.ORCID 0000-0003-2313-5461
Alessia BenedettiDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma 56, 56126 Pisa, Italy.
Antonello Di PaoloDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma 56, 56126 Pisa, Italy.ORCID 0000-0002-2661-6183
Domenico GianneseDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma 56, 56126 Pisa, Italy.ORCID 0000-0002-3773-9744
Adamasco CupistiDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma 56, 56126 Pisa, Italy.ORCID 0000-0002-8995-936X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drugs and food interact mutually: drugs may affect the nutritional status of the body, acting on senses, appetite, resting energy expenditure, and food intake; conversely, food or one of its components may affect bioavailability and half-life, circulating plasma concentrations of drugs resulting in an increased risk of toxicity and its adverse effects, or therapeutic failure. Therefore, the knowledge of these possible interactions is fundamental for the implementation of a nutritional treatment in the presence of a pharmacological therapy. This is the case of chronic kidney disease (CKD), for which the medication burden could be a problem, and nutritional therapy plays an important role in the patient's treatment. The aim of this paper was to review the interactions that take place between drugs and foods that can potentially be used in renal patients, and the changes in nutritional status induced by drugs. A proper definition of the amount of food/nutrient intake, an adequate definition of the timing of meal consumption, and a proper adjustment of the drug dosing schedule may avoid these interactions, safeguarding the quality of life of the patients and guaranteeing the effectiveness of drug therapy. Hence, a close collaboration between the nephrologist, the renal dietitian, and the patient is crucial. Dietitians should consider that food may interact with drugs and that drugs may affect nutritional status, in order to provide the patient with proper dietary suggestions, and to allow the maximum effectiveness and safety of drug therapy, while preserving/correcting the nutritional status.

Indexed as

Food-Drug InteractionsKidney DiseasesNutritional StatusAppetiteBiological AvailabilityDietEnergy MetabolismFoodHumansNutritionistsNutrition TherapyPharmacokineticsQuality of LifeCKDdietdrug interactionfoodmedicationnutrientsnutritional status

Identifiers

PMID35011087
PMCPMC8747252

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.