Evidence map›Paper›PMID 35011387›Full record

ArticleMolecules (Basel, Switzerland)2021

In Vitro Evaluation of the Anti-Diabetic Potential of Aqueous Acetone

Kolajo Adedamola Akinyede, Habeebat Adekilekun Oyewusi, Gail Denise Hughes, Okobi Eko Ekpo, Oluwafemi Omoniyi Oguntibeju

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 45 citations in OpenAlex.

  1. Chemical composition, antioxidant activities, and enzyme inhibitory effects ofJournal of enzyme inhibition and medicinal chemistry · 2025
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  3. Molecular modeling approach in design of new scaffold ofBiochemistry and biophysics reports · 2025
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  4. Pharmaceuticals (Basel, Switzerland) · 2024
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  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Chemical Constituents from the Leaves ofMolecules (Basel, Switzerland) · 2023
    Article
  12. Article
  13. Article
  14. Journal of diabetes and metabolic disorders · 2022
    Article
  15. Article
  16. Article
  17. Plants (Basel, Switzerland) · 2022
    Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 4 countries.

Kolajo Adedamola AkinyedeDepartment of Medical Bioscience, University of the Western Cape, Bellville, Cape Town 7530, South Africa.
Habeebat Adekilekun OyewusiBiochemistry Unit, Department of Science Technology, The Federal Polytechnic P.M.B.5351, Ado Ekiti 360231, Ekiti State, Nigeria.
Gail Denise HughesDepartment of Medical Bioscience, University of the Western Cape, Bellville, Cape Town 7530, South Africa.
Okobi Eko EkpoDepartment of Medical Bioscience, University of the Western Cape, Bellville, Cape Town 7530, South Africa.
Oluwafemi Omoniyi OguntibejuPhytomedicine and Phytochemistry Group, Oxidative Stress Research Centre, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7535, South Africa.ORCID 0000-0002-7299-1128
The Federal Polytechnic, Ado-Ekiti · NGCape Peninsula University of Technology · ZAKhalifa University of Science and Technology · AEUniversity of the Western Cape · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus (DM) is a chronic metabolic condition that can lead to significant complications and a high fatality rate worldwide. Efforts are ramping up to find and develop novel α-glucosidase and α-amylase inhibitors that are both effective and potentially safe. Traditional methodologies are being replaced with new techniques that are less complicated and less time demanding; yet, both the experimental and computational strategies are viable and complementary in drug discovery and development. As a result, this study was conducted to investigate the in vitro anti-diabetic potential of aqueous acetone

Indexed as

Molecular Docking SimulationMolecular Dynamics SimulationAcetonealpha-Amylasesalpha-GlucosidasesCell LineChromatography, LiquidDiabetes MellitusDose-Response Relationship, DrugDrug DiscoveryEnzyme ActivationGlycoside Hydrolase InhibitorsHelichrysumHumansHypoglycemic AgentsMass SpectrometryAcetonealpha-Amylasesalpha-GlucosidasesGlycoside Hydrolase InhibitorsHypoglycemic AgentsPhytochemicalsPlant Extractsdiabetes mellitusdrug discovery and developmentglucose uptakeα-amylase and α-glucosidase inhibitors

Identifiers

PMID35011387
PMCPMC8746515
OpenAlexW4200573698

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.