Evidence map›Paper›PMID 35011693›Full record

ArticleCells2021

Substrate- and Calcium-Dependent Differential Regulation of Mitochondrial Oxidative Phosphorylation and Energy Production in the Heart and Kidney.

Xiao Zhang, Namrata Tomar, Sunil M Kandel, Said H Audi, Allen W Cowley, Ranjan K Dash

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Mechanistic Modeling of MCUx Gatekeeping, CaAmerican journal of physiology. Cell physiology · 2026
    Article
  3. Mitochondria-ER crosstalk via MAMS: Bridging cellular homeostasis and cancer progression.Apoptosis : an international journal on programmed cell death · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Advances in fibroblast-based cardiac reprogramming in the treatment of heart disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  12. Article
  13. Review
  14. Article
  15. Complex II ambiguities-FADHThe Journal of biological chemistry · 2024
    Review
  16. Effects of ROS pathway inhibitors and NADH and FADHArchives of biochemistry and biophysics · 2023
    Article
  17. Article
  18. Asparaginyl endopeptidase contributes to cetuximab resistance via MEK/ERK signaling in RAS wide-type metastatic colorectal cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xiao ZhangDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Namrata TomarDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Sunil M KandelDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Said H AudiDepartment of Biomedical Engineering, Marquette University, Milwaukee, WI 53223, USA.
Allen W CowleyCenter of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Ranjan K DashDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Medical College of Wisconsin · USMarquette University · US

Funding

Therapeutic Effects of mTOR Inhibition in Salt-Sensitive HypertensionP01HL116264 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI MATTSON, DAVID L. · 2013 to 2021
$18.7M
High Salt Remodels Renal Cortical and Proximal Tubular Metabolism: Metabolic Fuels, Oxidative Stress, and HypertensionR01HL151587 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Allen W Cowley, Ranjan K Dash · 2021 to 2026
$3.7M
NHLBI NIH HHS P01 HL116264NHLBI NIH HHS R01 HL151587
6 · The paper itself

Abstract

Mitochondrial dehydrogenases are differentially stimulated by Ca

Indexed as

Energy MetabolismOxidative PhosphorylationAnimalsCalciumCell RespirationKidneyMitochondria, HeartModels, BiologicalOxygen ConsumptionRatsRats, Sprague-DawleySubstrate SpecificityTime FactorsCalciumATP synthesiscalcium regulationenergy metabolismmitochondrial respirationoxidative phosphorylationrespiratory controlsubstrate utilization

Identifiers

PMID35011693
PMCPMC8750792
OpenAlexW4205865583

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.