Evidence map›Paper›PMID 35012173›Full record

ArticlePolymers2021

The Elaboration of Effective Coatings for Photonic Crystal Chips in Optical Biosensors.

Svetlana Sizova, Ruslan Shakurov, Tatiana Mitko, Fedor Shirshikov, Daria Solovyeva, Valery Konopsky, Elena Alieva, Dmitry Klinov, Julia Bespyatykh, Dmitry Basmanov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Svetlana SizovaFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 1A Malaya Pirogovskaya St., 119435 Moscow, Russia.ORCID 0000-0003-0846-4670
Ruslan ShakurovFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 1A Malaya Pirogovskaya St., 119435 Moscow, Russia.
Tatiana MitkoFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 1A Malaya Pirogovskaya St., 119435 Moscow, Russia.
Fedor ShirshikovFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 1A Malaya Pirogovskaya St., 119435 Moscow, Russia.
Daria SolovyevaDepartment of Biomaterials and Bionanotechnology, Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.ORCID 0000-0002-2590-4204
Valery KonopskySolid State Spectroscopy Department, Institute of Spectroscopy RAS, 5 Fizicheskaya St., 108840 Moscow, Russia.ORCID 0000-0001-6114-5172
Elena AlievaSolid State Spectroscopy Department, Institute of Spectroscopy RAS, 5 Fizicheskaya St., 108840 Moscow, Russia.
Dmitry KlinovFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 1A Malaya Pirogovskaya St., 119435 Moscow, Russia.
Julia BespyatykhFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 1A Malaya Pirogovskaya St., 119435 Moscow, Russia.ORCID 0000-0002-4408-503X
Dmitry BasmanovFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 1A Malaya Pirogovskaya St., 119435 Moscow, Russia.ORCID 0000-0001-6620-7360
Moscow Institute of Physics and Technology · RUD. Mendeleyev University of Chemical Technology of Russia · RUInstitute of Bioorganic Chemistry · RUInstitute of Spectroscopy · RUFederal Medical-Biological Agency · RU

Funding

the Russian Foundation for Basic Research 20-75-10144
6 · The paper itself

Abstract

Here, we propose and study several types of quartz surface coatings designed for the high-performance sorption of biomolecules and their subsequent detection by a photonic crystal surface mode (PC SM) biosensor. The deposition and sorption of biomolecules are revealed by analyzing changes in the propagation parameters of optical modes on the surface of a photonic crystal (PC). The method makes it possible to measure molecular and cellular affinity interactions in real time by independently recording the values of the angle of total internal reflection and the angle of excitation of the surface wave on the surface of the PC. A series of dextrans with various anchor groups (aldehyde, carboxy, epoxy) suitable for binding with bioligands have been studied. We have carried out comparative experiments with dextrans with other molecular weights. The results confirmed that dextran with a Mw of 500 kDa and anchor epoxy groups have a promising potential as a matrix for the detection of proteins in optical biosensors. The proposed approach would make it possible to enhance the sensitivity of the PC SM biosensor and also permit studying the binding process of low molecular weight molecules in real time.

Indexed as

biomolecular interactionbiosensor coatingdextranlabel-free detectionmicrofluidicsoptical surface wavesphotonic crystal surface mode biosensorprotein binding

Identifiers

PMID35012173
PMCPMC8747551
OpenAlexW4206832105

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.