Evidence map›Paper›PMID 35012650›Full record

SynthesisStem cell research & therapy2022

When stem cells meet COVID-19: recent advances, challenges and future perspectives.

Shasha Li, Hecheng Zhu, Ming Zhao, Weidong Liu, Lei Wang, Bin Zhu, Wen Xie, Cong Zhao, Yao Zhou, Caiping Ren and 2 more

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Stem cell research & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Merits and challenges of iPSC-derived organoids for clinical applications.Frontiers in cell and developmental biology · 2023
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 4 countries.

Shasha LiCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.
Hecheng ZhuChangsha Kexin Cancer Hospital, Changsha, 410205, China.
Ming ZhaoChangsha Kexin Cancer Hospital, Changsha, 410205, China.
Weidong LiuCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.
Lei WangCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.
Bin ZhuCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.
Wen XieCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.
Cong ZhaoCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.
Yao ZhouCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.
Caiping RenCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China. rencaiping@csu.edu.cn.ORCID 0000-0001-6880-7394
Hui LiuSchool of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. liuhui@wmu.edu.cn.
Xingjun JiangCancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China. jiangxj@csu.edu.cn.
Central South University · CNZhejiang Cancer Hospital · CNWenzhou Medical University · CN

Funding

Hunan Provincial Science and Technology Department 2014FJ6006Independent Exploration and Innovation Project of Central South University 2020zzts235National Key Research and Development Program of China 2016YFC1101502National Natural Science Foundation of China 81070993National Natural Science Foundation of China 81773179National Natural Science Foundation of China 82071399National Natural Science Foundation of China 82101143Natural Science Foundation of Hunan Province 2016JJ2172Natural Science Foundation of Hunan Province 2020JJ4771Natural Science Foundation of Zhejiang Province LQ20C120001
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory coronavirus 2 is currently spreading throughout the world with a high rate of infection and mortality and poses a huge threat to global public health. COVID-19 primarily manifests as hypoxic respiratory failure and acute respiratory distress syndrome, which can lead to multiple organ failure. Despite advances in the supportive care approaches, there is still a lack of clinically effective therapies, and there is an urgent need to develop novel strategies to fight this disease. Currently, stem cell therapy and stem cell-derived organoid models have received extensive attention as a new treatment and research method for COVID-19. Here, we discuss how stem cells play a role in the battle against COVID-19 and present a systematic review and prospective of the study on stem cell treatment and organoid models of COVID-19, which provides a reference for the effective control of the COVID-19 pandemic worldwide.

Indexed as

COVID-19PandemicsHumansProspective StudiesSARS-CoV-2Stem CellsCOVID-19MSCsOrganoid modelsSARS-CoV-2Stem cell threapy

Identifiers

PMID35012650
PMCPMC8744050
OpenAlexW4206381257

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.