Evidence map›Paper›PMID 35013222›Full record

ArticleNature communications2022

Transient neuronal suppression for exploitation of new sensory evidence.

Maxwell Shinn, Daeyeol Lee, John D Murray, Hyojung Seo

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Neural correlates of perceptual decision-making in the primary somatosensory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Rapid Motor Inhibition as a Mechanism to Prevent Outdated Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Phantom oscillations in principal component analysis.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maxwell ShinnInterdepartmental Neuroscience Program, Yale University, New Haven, CT, 06520, USA.ORCID http://orcid.org/0000-0002-7424-4230
Daeyeol LeeZanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID http://orcid.org/0000-0003-3474-019X
John D MurrayInterdepartmental Neuroscience Program, Yale University, New Haven, CT, 06520, USA. john.murray@yale.edu.ORCID http://orcid.org/0000-0003-4115-8181
Hyojung SeoInterdepartmental Neuroscience Program, Yale University, New Haven, CT, 06520, USA. hyojung.seo@yale.edu.ORCID http://orcid.org/0000-0002-2928-9018

Funding

Neural Basis of temporal decision makingR01MH108629 · NIMH · YALE UNIVERSITY · PI LEE, DAEYEOL · 2016 to 2020
$2.2M
Linking Large-Scale Dysconnectivity in Schizophrenia to Cortical Circuit Function at the Individual Level through Computational Modeling and Multimodal NeuroimagingR01MH112746 · NIMH · YALE UNIVERSITY · PI MURRAY, JOHN DAVID · 2017 to 2020
$1.7M
NIMH NIH HHS R01 MH108629NIMH NIH HHS R01 MH112746
6 · The paper itself

Abstract

In noisy but stationary environments, decisions should be based on the temporal integration of sequentially sampled evidence. This strategy has been supported by many behavioral studies and is qualitatively consistent with neural activity in multiple brain areas. By contrast, decision-making in the face of non-stationary sensory evidence remains poorly understood. Here, we trained monkeys to identify and respond via saccade to the dominant color of a dynamically refreshed bicolor patch that becomes informative after a variable delay. Animals' behavioral responses were briefly suppressed after evidence changes, and many neurons in the frontal eye field displayed a corresponding dip in activity at this time, similar to that frequently observed after stimulus onset but sensitive to stimulus strength. Generalized drift-diffusion models revealed consistency of behavior and neural activity with brief suppression of motor output, but not with pausing or resetting of evidence accumulation. These results suggest that momentary arrest of motor preparation is important for dynamic perceptual decision making.

Indexed as

AnimalsBrainDecision MakingFrontal LobeMacaca mulattaMaleNeuronsPhotic StimulationSaccades

Identifiers

PMID35013222
PMCPMC8748884

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.